Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 2;13(2):185.
doi: 10.3390/ijerph13020185.

The Relationship between AMH and AMHR2 Polymorphisms and the Follicular Phase in Late Reproductive Stage Women

Anna Jurczak  1 , Małgorzata Szkup  2 , Anna Grzywacz  3 , Krzysztof Safranow  4 , Elżbieta Grochans  5
Affiliations

The Relationship between AMH and AMHR2 Polymorphisms and the Follicular Phase in Late Reproductive Stage Women

Anna Jurczak et al. Int J Environ Res Public Health. .

Abstract

The objective of this work was the analysis of the relationships between the genotypes of the AMH and AMH receptor type 2 genes, hormone levels and the menstrual cycle in a group of Polish women in the late reproductive stage. The study was conducted using a measurement-based method (body weight and height), laboratory method (serum hormone levels AMH, FSH and E2), and genetic analysis (DNA isolated from whole blood by a salting-out method). The study involved 345 healthy, late-reproductive-stage women from Poland, aged 42.3 ± 4.5 years. The analysis demonstrated that neither the T/T and G/T+G/G genotypes of the AMH Ile(49)Ser polymorphism (rs10407022), nor the A/A and the G/A + G/G genotypes of the AMHR2 2482 A > G polymorphism (rs2002555), nor the C/C and C/T + T/T genotypes of the AMH polymorphism (rs11170547) were statistically significantly related (p > 0.05) to such factors as age, BMI, hormone (FSH and E₂) levels and ovarian parameters (AMH) in the follicular phase. No relationships were found between ovarian parameters (FSH, E₂, AMH) and genetic variants of AMH (rs10407022) and AMHR2 (rs11170547, rs2002555) in healthy women in the late reproductive stage.

Keywords: AMH; AMHR2; follicular phase; late reproductive stage.

PubMed Disclaimer

References

    1. Durlinger A.L.L., Visser J.A., Themmen A.P.N. Regulation of ovarian function: The role of anti-Mullerian hormone. Reproduction. 2002;124:601–609. doi: 10.1530/rep.0.1240601. - DOI - PubMed
    1. Durlinger A.L.L., Gruijters M.J.G., Kramer P., Karels B., Kumar T.R., Matzuk M.M., Rose U.M., de Jong F.H., Uilenbroek J.T.J., Grootegoed J.A., et al. Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology. 2001;142:4891–4899. - PubMed
    1. Van Rooij I.A.J., Broekmans F.J.M., te Velde E.R., Fauser B.C.J.M., Bancsi L.F., de Jong F.H., Themmen A.P.N. Serum anti-Mullerian hormone levels: A novel measure of ovarian reserve. Hum. Reprod. 2002;17:3065–3071. doi: 10.1093/humrep/17.12.3065. - DOI - PubMed
    1. Kevenaar M.E., Themmen A.P.N., Rivadeneira F., Uitterlinden A.G., Laven J.S.E., van Schoor N.M., Lips P., Pols H.A.P., Visser J.A. A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity. Hum. Reprod. 2007;22:2382–2388. doi: 10.1093/humrep/dem176. - DOI - PubMed
    1. Riggs R.M., Duran E.H., Baker M.W., Kimble T.D., Hobeika E., Yin L., Matos-Bodden L., Leader B., Stadtmauer L. Assessment of ovarian reserve the anti-mullerian hormone: A comparison of the predictive value of anti-mullerian hormone, follicle stimulating hormone, inhibin B and age. Am. J. Obstet. Gynecol. 2008 doi: 10.1016/j.ajog.2008.05.004. - DOI - PubMed

Publication types

LinkOut - more resources