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Review
. 2016 Feb 2;5(1):14.
doi: 10.3390/pathogens5010014.

Genetic Variations in Vesicoureteral Reflux Sequelae

David S Hains  1 , Andrew L Schwaderer  2
Affiliations
Review

Genetic Variations in Vesicoureteral Reflux Sequelae

David S Hains et al. Pathogens. .

Abstract

Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI.

Keywords: copy number variations; genetics; urinary tract infections; vesicoureteral reflux.

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Figures

Figure 1
Figure 1
Comparative Genomic Hybridization. (A) Equal amounts test and reference DNA samples are labeled respectively and mixed; (B) Mixture is applied to an array and allowed to hybridize; (C) Red and green signal intensity is detected and mapped to genome location; (D) Software clusters high and low intensity probes according to log2 intensity ratio of test to reference; (E) Example of a number of probes representing a copy number loss in test sample.
See this image and copyright information in PMC

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References

    1. Spencer J.D., Schwaderer A.L., Becknell B., Watson J., Hains D.S. The innate immune response during urinary tract infection and pyelonephritis. Pediatr. Nephrol. 2014;29:1139–1149. doi: 10.1007/s00467-013-2513-9. - DOI - PMC - PubMed
    1. Craig J.C., Irwig L.M., Knight J.F., Roy L.P. Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics. 2000;105:1236–1241. doi: 10.1542/peds.105.6.1236. - DOI - PubMed
    1. Spencer J.D., Schwaderer A., McHugh K., Vanderbrink B., Becknell B., Hains D.S. The demographics and costs of inpatient vesicoureteral reflux management in the USA. Pediatr. Nephrol. 2011;26:1995–2001. doi: 10.1007/s00467-011-1900-3. - DOI - PubMed
    1. Kass E.J., Kernen K.M., Carey J.M. Paediatric urinary tract infection and the necessity of complete urological imaging. BJU Int. 2000;86:94–96. doi: 10.1046/j.1464-410x.2000.00728.x. - DOI - PubMed
    1. Stokland E., Hellström M., Jacobsson B., Jodal U., Sixt R. Evaluation of DMSA scintigraphy and urography in assessing both acute and permanent renal damage in children. Acta Radiol. 1998;39:447–452. doi: 10.1080/02841859809172462. - DOI - PubMed

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