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Observational Study
. 2015;20(8):557-64.
doi: 10.3109/1354750X.2015.1105498. Epub 2016 Feb 5.

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Stefan Kluzek  1   2 , Anne-Christine Bay-Jensen  3 , Andrew Judge  1   4 , Morten A Karsdal  3 , Matthew Shorthose  5 , Tim Spector  6 , Deborah Hart  6 , Julia L Newton  2 , Nigel K Arden  1   2   4
Affiliations
Observational Study

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

Stefan Kluzek et al. Biomarkers. 2015.

Abstract

Context and objective: We evaluated the predictive value of serum cartilage oligomeric matrix protein (sCOMP) levels over 20 years on the development of radiographic (RKOA) and painful knee osteoarthritis (KOA) in a longitudinal cohort of middle-aged women.

Materials and methods: Five hundred and ninety-three women with no baseline KOA underwent 5-year knee radiographs over 20-years and were asked about knee pain a month before each assessment. A repeated measures logistic regression model was used where the outcomes were recorded at 5, 10, 15 and 20-years follow-up.

Results: The highest quartile of sCOMP was associated with increased risk of RKOA with overall OR of 1.97 (95% CI: 1.33-2.91) over 20 years when compared with the lowest sCOMP quartile. The association with painful KOA was similar and also independent, but only when the fourth and third sCOMP quartiles were compared.

Discussion and conclusion: This study demonstrates that sCOMP levels are predictive of subsequent structural changes and incidence of painful KOA, independently of age and BMI.

Keywords: COMP; Cohort; epidemiology; knee; osteoarthritis.

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Figures

Figure 1.
Figure 1.
The Venn diagrams illustrate the relationship between the radiographic, painful and symptomatic KOA, during each follow-up visit of the cohort with no RKOA at baseline (n = 593). RKOA, radiographic knee osteoarthritis; painful RKOA, any knee pain reported in the last month and K/L score ≥2 on the same site; symptomatic RKOA, knee pain for 15 d or more in the last month and the K/L score ≥2.
Figure 2.
Figure 2.
Serum COMP quartile sand the risk of developing RKOA. The results are adjusted for baseline age and BMI. The bottom line consists of the overlapping lines for the first and second sCOMP quartiles.
Figure 3.
Figure 3.
Serum COMP quartiles and the risk of developing painful RKOA. The results are adjusted for baseline age and BMI.
Figure 4.
Figure 4.
Serum COMP quartiles and the risk of developing symptomatic RKOA. The results are adjusted for baseline age and BMI.
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