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. 2016 Feb 19;81(4):1675-80.
doi: 10.1021/acs.joc.5b02903. Epub 2016 Feb 5.

Kinetic Control of Rh(III)-Catalyzed Annulation of C-H Bonds with Quinones: Chemoselective Synthesis of Hydrophenanthridinones and Phenanthridinones

Wei Yang  1 , Jingyi Wang  1 , Zhonglin Wei  2 , Qian Zhang  1 , Xianxiu Xu  1
Affiliations

Kinetic Control of Rh(III)-Catalyzed Annulation of C-H Bonds with Quinones: Chemoselective Synthesis of Hydrophenanthridinones and Phenanthridinones

Wei Yang et al. J Org Chem. .

Abstract

A temperature-dependent redox-neutral Rh(III)-catalyzed C-H bond annulation of N-methoxybenzamides with quinones was developed for the chemoselective synthesis of hydrophenanthridinones and phenanthridinones. This reaction involves an Rh(III)-catalyzed C-H bond functionalization and a subsequent cyclization through the directing group nucleophilic addition to the carbonyl group at room temperature.

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