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. 2016 Feb 5;6(2):e390.
doi: 10.1038/bcj.2016.3.

Continued improvement in survival of acute myeloid leukemia patients: an application of the loss in expectation of life

H Bower  1 , T M-L Andersson  1 , M Björkholm  2 , P W Dickman  1 , P C Lambert  1   3 , Å R Derolf  2
Affiliations

Continued improvement in survival of acute myeloid leukemia patients: an application of the loss in expectation of life

H Bower et al. Blood Cancer J. .

Abstract

We evaluated temporal trends in survival of Swedish acute myeloid leukemia (AML) patients diagnosed between 1973 and 2011 using relative survival ratios (RSRs) and a measure called the loss in expectation of life (LEL). RSRs increased most for patients <60 years at diagnosis during the first calendar periods, but between 1997-2005 and 2006-2011 the most pronounced increase was for those aged 61-70 years at diagnosis; RSR changed from 0.16 (95% confidence interval (CI): 0.13-0.19) to 0.28 (95% CI: 0.23-0.33), respectively. The LEL for males aged 35 years at diagnosis was 41.0 (95% CI: 40.1-41.8) years in 1975 and 19.5 (95% CI: 16.4-22.5) years in 2011. For males aged 65 years, the corresponding figures were 13.8 (95% CI: 13.7-14.0) and 12.0 (95% CI: 11.3-12.8). Conditional LEL estimates suggested that patients who survive 5 years postdiagnosis have shorter remaining lifespan than the general population. The proportion of expected life lost (PELL) suggested that male 65-year-old patients lost 75% of their life expectancy in 2005 and 66% if they were diagnosed in 2011. Survival continued to increase to 2011, with larger improvements in those aged 61-70 years at diagnosis. The LEL and PELL are intuitive measures that may be useful in communicating survival statistics to patients, clinicians and health-care providers.

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Figures

Figure 1
Figure 1
Five-year RSRs of Swedish AML patients stratified by age category over calendar period.
Figure 2
Figure 2
Temporal trends in the life expectancy of the general population (dashed lines) and AML patients (solid lines) in Sweden.
Figure 3
Figure 3
Temporal trends in the PELL of Swedish AML patients, with 95% CIs.
Figure 4
Figure 4
One- and 5-year conditional LEL of Swedish AML patients by sex over year of diagnosis.
See this image and copyright information in PMC

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