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Comment
. 2016 Feb 4;18(2):168-9.
doi: 10.1016/j.stem.2016.01.011.

CDX2: Linking Cell and Patient Fates in Colon Cancer

Eric R Fearon  1 , Emina H Huang  2
Affiliations
Comment

CDX2: Linking Cell and Patient Fates in Colon Cancer

Eric R Fearon et al. Cell Stem Cell. .

Abstract

Administering adjuvant chemotherapy to stage II colon cancer patients is controversial due to limited benefit observed for this subpopulation. Recently, Dalerba et al. (2016) identified a subgroup of stage II patients that might benefit from adjuvant chemotherapy based on lack of CDX2 expression in their cancer stem cells.

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Comment on

  • CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.
    Dalerba P, Sahoo D, Paik S, Guo X, Yothers G, Song N, Wilcox-Fogel N, Forgó E, Rajendran PS, Miranda SP, Hisamori S, Hutchison J, Kalisky T, Qian D, Wolmark N, Fisher GA, van de Rijn M, Clarke MF. Dalerba P, et al. N Engl J Med. 2016 Jan 21;374(3):211-22. doi: 10.1056/NEJMoa1506597. N Engl J Med. 2016. PMID: 26789870 Free PMC article.

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