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Case Reports
. 2016 Jun;41(3):351-353.
doi: 10.1111/jcpt.12359. Epub 2016 Feb 6.

'On-demand' romiplostim therapy in immune thrombocytopenia

M Mitrovic  1   2 , I Elezovic  1   2 , N Suvajdzic-Vukovic  1   2
Affiliations
Case Reports

'On-demand' romiplostim therapy in immune thrombocytopenia

M Mitrovic et al. J Clin Pharm Ther. 2016 Jun.

Abstract

What is known and objective: Although thrombopoietin receptor agonists are a second-line treatment for refractory immune thrombocytopenia (ITP), we lack guidelines recommending maintenance modality in patients who achieve complete remission (CR).

Case summary: We report a patient with refractory ITP who achieved CR on romiplostim. Obtaining romiplostim for 6 months of therapy, we decided to try extending this by modifying the standard treatment regimen. Romiplostim was successfully administered 'on-demand', only if the patient's platelet count dropped below 150 × 109 /L, over a period of 12 months.

What is new and conclusion: The strategy of 'on-demand' therapy is a promising procedure for the maintenance of response, lowering costs and improving treatment safety.

Keywords: immune thrombocytopenia; thrombopoietin receptor agonists; ‘on-demand’ therapy.

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