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Review
. 2016 Apr:100:117-26.
doi: 10.1016/j.critrevonc.2016.01.020. Epub 2016 Jan 23.

Understanding the FOLFOXIRI-regimen to optimize treatment for metastatic colorectal cancer

Yu Sunakawa  1 , Marta Schirripa  2 , Heinz-Josef Lenz  3
Affiliations
Review

Understanding the FOLFOXIRI-regimen to optimize treatment for metastatic colorectal cancer

Yu Sunakawa et al. Crit Rev Oncol Hematol. 2016 Apr.

Abstract

The management of metastatic colorectal cancer substantially improved over the last 10 years and median overall survival of patients might exceed 30 months. The selection of an effective first-line treatment represents a crucial point in order to achieve good outcome results. In the last years, the intensive FOLFOXIRI regimen in combination with bevacizumab became a new standard option in this setting. In the present review we summarized the main steps of FOLFOXIRI regimen development from the first pilot study to the recent findings with biological agents, with a specific focus on practical aspects, such as patient's selection, adverse event management, treatment schedules and post-progression strategies. Possible predictive markers, open issues and ongoing clinical trials have been also deeply described.

Keywords: Anti-EGFR; Bevacizumab; FOLFOXIRI; First-line; Metastatic colorectal cancer.

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Conflict of interest statement

Conflict of interest

The authors have declared no conflicts of interest.

Figures

Figure 1
Figure 1
Main ongoing trials evaluating the triplet chemotherapy plus biologic agents in patients with mCRC
See this image and copyright information in PMC

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