Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

doi:10.1186/s13005-016-0106-0

Review

. 2016 Feb 5:12:11.

doi: 10.1186/s13005-016-0106-0.

Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

L Feller^{1

2}, R A G Khammissa³, B Kramer⁴, M Altini⁵, J Lemmer³

Affiliations

¹ Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa. liviu.feller@smu.ac.za.
² Department Periodontology and Oral Medicine, Box D26 School of Dentistry, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa. liviu.feller@smu.ac.za.
³ Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa.
⁴ School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Division of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.

PMID: 26850723
PMCID: PMC4744388
DOI: 10.1186/s13005-016-0106-0

Review

Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

L Feller et al. Head Face Med. 2016.

. 2016 Feb 5:12:11.

doi: 10.1186/s13005-016-0106-0.

Authors

L Feller^{1

2}, R A G Khammissa³, B Kramer⁴, M Altini⁵, J Lemmer³

Affiliations

¹ Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa. liviu.feller@smu.ac.za.
² Department Periodontology and Oral Medicine, Box D26 School of Dentistry, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa. liviu.feller@smu.ac.za.
³ Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa.
⁴ School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Division of Anatomical Pathology, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.

PMID: 26850723
PMCID: PMC4744388
DOI: 10.1186/s13005-016-0106-0

Abstract

Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways.Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the pathogenesis of cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma apart from their role in determining a cancer-prone pigmentory phenotype (fair skin, red hair, blue eyes) through their interactions with other genes regulating immuno-inflammatory responses, DNA repair or apoptosis.In this short review we focus on the aetiological role of UV in cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin, and on some associated biopathological events.

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References

1. Brash DE, Heffernan T, Ngheim P. Carcinogenesis: Ultravoilet radiation. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill; 2008. pp. 999–1006.
1. Donovan J. Review of the hair follicle origin hypothesis for basal cell carcinoma. Dermatol Surg. 2009;35(9):1311–1323. doi: 10.1111/j.1524-4725.2009.01236.x. - DOI - PubMed
1. Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y, et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol. 2010;12(3):299–305. - PubMed
1. Tlholoe MM, Khammissa RA, Bouckaert M, Altini M, Lemmer J, Feller L. Oral Mucosal Melanoma: Some Pathobiological Considerations and an Illustrative Report of a Case. Head Neck Pathol. 2015;9(1):127–134. doi: 10.1007/s12105-014-0526-8. - DOI - PMC - PubMed
1. Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8(10):743–754. doi: 10.1038/nrc2503. - DOI - PMC - PubMed

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[1] Brash DE, Heffernan T, Ngheim P. Carcinogenesis: Ultravoilet radiation. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill; 2008. pp. 999–1006.

[2] Brash DE, Heffernan T, Ngheim P. Carcinogenesis: Ultravoilet radiation. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick's Dermatology in General Medicine. New York: McGraw-Hill; 2008. pp. 999–1006.

[3] Donovan J. Review of the hair follicle origin hypothesis for basal cell carcinoma. Dermatol Surg. 2009;35(9):1311–1323. doi: 10.1111/j.1524-4725.2009.01236.x. - DOI - PubMed

[4] Donovan J. Review of the hair follicle origin hypothesis for basal cell carcinoma. Dermatol Surg. 2009;35(9):1311–1323. doi: 10.1111/j.1524-4725.2009.01236.x. - DOI - PubMed

[5] Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y, et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol. 2010;12(3):299–305. - PubMed

[6] Youssef KK, Van Keymeulen A, Lapouge G, Beck B, Michaux C, Achouri Y, et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol. 2010;12(3):299–305. - PubMed

[7] Tlholoe MM, Khammissa RA, Bouckaert M, Altini M, Lemmer J, Feller L. Oral Mucosal Melanoma: Some Pathobiological Considerations and an Illustrative Report of a Case. Head Neck Pathol. 2015;9(1):127–134. doi: 10.1007/s12105-014-0526-8. - DOI - PMC - PubMed

[8] Tlholoe MM, Khammissa RA, Bouckaert M, Altini M, Lemmer J, Feller L. Oral Mucosal Melanoma: Some Pathobiological Considerations and an Illustrative Report of a Case. Head Neck Pathol. 2015;9(1):127–134. doi: 10.1007/s12105-014-0526-8. - DOI - PMC - PubMed

[9] Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8(10):743–754. doi: 10.1038/nrc2503. - DOI - PMC - PubMed

[10] Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8(10):743–754. doi: 10.1038/nrc2503. - DOI - PMC - PubMed

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Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

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Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face

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