Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

doi:10.1016/j.resuscitation.2016.01.012

Randomized Controlled Trial

. 2016 Apr:101:57-64.

doi: 10.1016/j.resuscitation.2016.01.012. Epub 2016 Feb 2.

Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

Affiliations

¹ Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States. Electronic address: hwang@uabmc.edu.
² Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: dprince@uw.edu.
³ Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States. Electronic address: swstephens@uabmc.edu.
⁴ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: hherren@uw.edu.
⁵ Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, United States. Electronic address: dayam@ohsu.edu.
⁶ MedStar, Inc., Fort Worth, TX, United States. Electronic address: nrichmond@medstar911.org.
⁷ St Vincent's Medical Center, Erie, PA, United States; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: jcarlson@svhs.org.
⁸ Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, United States. Electronic address: wardenc@ohsu.edu.
⁹ Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: colella@mcw.edu.
¹⁰ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: brienzaam@upmc.edu.
¹¹ Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: taufderh@mcw.edu.
¹² Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: aidris@sbcglobal.net.
¹³ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: rschmick@uw.edu.
¹⁴ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: sjmay@uw.edu.
¹⁵ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: nichol@uw.edu.

PMID: 26851059
PMCID: PMC4792760
DOI: 10.1016/j.resuscitation.2016.01.012

Randomized Controlled Trial

Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

Henry E Wang et al. Resuscitation. 2016 Apr.

. 2016 Apr:101:57-64.

doi: 10.1016/j.resuscitation.2016.01.012. Epub 2016 Feb 2.

Authors

Affiliations

¹ Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States. Electronic address: hwang@uabmc.edu.
² Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: dprince@uw.edu.
³ Department of Emergency Medicine, University of Alabama School of Medicine, Birmingham, AL, United States. Electronic address: swstephens@uabmc.edu.
⁴ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: hherren@uw.edu.
⁵ Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, United States. Electronic address: dayam@ohsu.edu.
⁶ MedStar, Inc., Fort Worth, TX, United States. Electronic address: nrichmond@medstar911.org.
⁷ St Vincent's Medical Center, Erie, PA, United States; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: jcarlson@svhs.org.
⁸ Department of Emergency Medicine, Oregon Health and Science University, Portland, OR, United States. Electronic address: wardenc@ohsu.edu.
⁹ Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: colella@mcw.edu.
¹⁰ Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address: brienzaam@upmc.edu.
¹¹ Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, United States. Electronic address: taufderh@mcw.edu.
¹² Department of Emergency Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: aidris@sbcglobal.net.
¹³ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: rschmick@uw.edu.
¹⁴ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: sjmay@uw.edu.
¹⁵ Clinical Trials Center, Department of Biostatistics, University of Washington, Seattle, WA, United States. Electronic address: nichol@uw.edu.

PMID: 26851059
PMCID: PMC4792760
DOI: 10.1016/j.resuscitation.2016.01.012

Abstract

Airway management is an important component of resuscitation from out-of-hospital cardiac arrest (OHCA). The optimal approach to advanced airway management is unknown. The Pragmatic Airway Resuscitation Trial (PART) will compare the effectiveness of endotracheal intubation (ETI) and Laryngeal Tube (LT) insertion upon 72-h survival in adult OHCA. Encompassing United States Emergency Medical Services agencies affiliated with the Resuscitation Outcomes Consortium (ROC), PART will use a cluster-crossover randomized design. Participating subjects will include adult, non-traumatic OHCA requiring bag-valve-mask ventilation. Trial interventions will include (1) initial airway management with ETI and (2) initial airway management with LT. The primary and secondary trial outcomes are 72-h survival and return of spontaneous circulation. Additional clinical outcomes will include airway management process and adverse events. The trial will enroll a total of 3000 subjects. Results of PART may guide the selection of advanced airway management strategies in OHCA.

Keywords: Airway management; Cardiopulmonary arrest; Clinical trials; Emergency medical services; Intubation (intratracheal); Resuscitation.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

The authors declare no financial or other conflicts of interest.

Figures

**FIGURE 1**
Resuscitation Outcomes Consortium centers participating in PART.

**FIGURE 2**
Overview of PART protocol. ETI = endotracheal intubation. LT = laryngeal tube. BVM = bag-valve-mask ventilation. EMS = Emergency Medical Services.

See this image and copyright information in PMC

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References

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1. Institute of Medicine. [Accessed October 9, 2015];Strategies to Improve Cardiac Arrest Survival: A Time to Act. 2015 at http://www.nap.edu/read/21723/chapter/1.
1. DeLeo BC. Endotracheal intubation by rescue squad personnel. Heart Lung. 1977;6:851–854. - PubMed
1. Guss DA, Posluszny M. Paramedic orotracheal intubation: a feasibility study. Am J Emerg Med. 1984;2:399–401. - PubMed
1. Jacobs LM, Berrizbeitia LD, Bennett B, Madigan C. Endotracheal intubation in the prehospital phase of emergency medical care. Jama. 1983;250:2175–2177. - PubMed

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[1] Go AS, Mozaffarian D, Roger VL, et al. Heart Disease and Stroke Statistics--2014 Update: A Report From the American Heart Association. Circulation. 2013 - PMC - PubMed

[2] Go AS, Mozaffarian D, Roger VL, et al. Heart Disease and Stroke Statistics--2014 Update: A Report From the American Heart Association. Circulation. 2013 - PMC - PubMed

[3] Institute of Medicine. [Accessed October 9, 2015];Strategies to Improve Cardiac Arrest Survival: A Time to Act. 2015 at http://www.nap.edu/read/21723/chapter/1.

[4] Institute of Medicine. [Accessed October 9, 2015];Strategies to Improve Cardiac Arrest Survival: A Time to Act. 2015 at http://www.nap.edu/read/21723/chapter/1.

[5] DeLeo BC. Endotracheal intubation by rescue squad personnel. Heart Lung. 1977;6:851–854. - PubMed

[6] DeLeo BC. Endotracheal intubation by rescue squad personnel. Heart Lung. 1977;6:851–854. - PubMed

[7] Guss DA, Posluszny M. Paramedic orotracheal intubation: a feasibility study. Am J Emerg Med. 1984;2:399–401. - PubMed

[8] Guss DA, Posluszny M. Paramedic orotracheal intubation: a feasibility study. Am J Emerg Med. 1984;2:399–401. - PubMed

[9] Jacobs LM, Berrizbeitia LD, Bennett B, Madigan C. Endotracheal intubation in the prehospital phase of emergency medical care. Jama. 1983;250:2175–2177. - PubMed

[10] Jacobs LM, Berrizbeitia LD, Bennett B, Madigan C. Endotracheal intubation in the prehospital phase of emergency medical care. Jama. 1983;250:2175–2177. - PubMed

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Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

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Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART)

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