Review

. 2016 Oct:40-41:48-81.

doi: 10.1016/j.semcancer.2016.02.001. Epub 2016 Feb 4.

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Nagendra Sastry Yarla¹, Anupam Bishayee², Gautam Sethi³, Pallu Reddanna⁴, Arunasree M Kalle⁵, Bhadrapura Lakkappa Dhananjaya⁶, Kaladhar S V G K Dowluru⁷, Ramakrishna Chintala⁸, Govinda Rao Duddukuri⁹

Affiliations

¹ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India.
² Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, 18301 N. Miami Avenue, Miami, FL 33169, USA. Electronic address: abishayee@ULarkin.org.
³ Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia.
⁴ Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, India.
⁵ Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, India; Department of Environmental Health Sciences, Laboratory of Human Environmental Epigenomes, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
⁶ Toxinology/Toxicology and Drug Discovery Unit, Center for Emerging Technologies, Jain Global Campus, Jain University, Kanakapura Taluk, Ramanagara 562 112, Karnataka, India.
⁷ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India; Department of Microbiology and Bioinformatics, Bilaspur University, Bilaspur 495 001, Chhattisgarh, India.
⁸ Department of Environmental Sciences, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India.
⁹ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India. Electronic address: drdgraoresearchgroup@gmail.com.

PMID: 26853158
DOI: 10.1016/j.semcancer.2016.02.001

Review

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Nagendra Sastry Yarla et al. Semin Cancer Biol. 2016 Oct.

. 2016 Oct:40-41:48-81.

doi: 10.1016/j.semcancer.2016.02.001. Epub 2016 Feb 4.

Authors

Affiliations

¹ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India.
² Department of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, 18301 N. Miami Avenue, Miami, FL 33169, USA. Electronic address: abishayee@ULarkin.org.
³ Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University, Western Australia 6009, Australia.
⁴ Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, India.
⁵ Department of Animal Biology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500 046, Telagana, India; Department of Environmental Health Sciences, Laboratory of Human Environmental Epigenomes, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
⁶ Toxinology/Toxicology and Drug Discovery Unit, Center for Emerging Technologies, Jain Global Campus, Jain University, Kanakapura Taluk, Ramanagara 562 112, Karnataka, India.
⁷ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India; Department of Microbiology and Bioinformatics, Bilaspur University, Bilaspur 495 001, Chhattisgarh, India.
⁸ Department of Environmental Sciences, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India.
⁹ Department of Biochemisty/Bionformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Adhra Pradesh, India. Electronic address: drdgraoresearchgroup@gmail.com.

PMID: 26853158
DOI: 10.1016/j.semcancer.2016.02.001

Abstract

Arachidonic acid (AA) pathway, a metabolic process, plays a key role in carcinogenesis. Hence, AA pathway metabolic enzymes phospholipase A₂s (PLA₂s), cyclooxygenases (COXs) and lipoxygenases (LOXs) and their metabolic products, such as prostaglandins and leukotrienes, have been considered novel preventive and therapeutic targets in cancer. Bioactive natural products are a good source for development of novel cancer preventive and therapeutic drugs, which have been widely used in clinical practice due to their safety profiles. AA pathway inhibitory natural products have been developed as chemopreventive and therapeutic agents against several cancers. Curcumin, resveratrol, apigenin, anthocyans, berberine, ellagic acid, eugenol, fisetin, ursolic acid, [6]-gingerol, guggulsteone, lycopene and genistein are well known cancer chemopreventive agents which act by targeting multiple pathways, including COX-2. Nordihydroguaiaretic acid and baicalein can be chemopreventive molecules against various cancers by inhibiting LOXs. Several PLA₂s inhibitory natural products have been identified with chemopreventive and therapeutic potentials against various cancers. In this review, we critically discuss the possible utility of natural products as preventive and therapeutic agents against various oncologic diseases, including prostate, pancreatic, lung, skin, gastric, oral, blood, head and neck, colorectal, liver, cervical and breast cancers, by targeting AA pathway. Further, the current status of clinical studies evaluating AA pathway inhibitory natural products in cancer is reviewed. In addition, various emerging issues, including bioavailability, toxicity and explorability of combination therapy, for the development of AA pathway inhibitory natural products as chemopreventive and therapeutic agents against human malignancy are also discussed.

Keywords: Arachidonic acid pathway; Bioactive natural products; Cancer; Prevention; Therapy.

PubMed Disclaimer

Cited by

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.
Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW. Wang B, et al. Signal Transduct Target Ther. 2021 Feb 26;6(1):94. doi: 10.1038/s41392-020-00443-w. Signal Transduct Target Ther. 2021. PMID: 33637672 Free PMC article. Review.
An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.
Roy NK, Parama D, Banik K, Bordoloi D, Devi AK, Thakur KK, Padmavathi G, Shakibaei M, Fan L, Sethi G, Kunnumakkara AB. Roy NK, et al. Int J Mol Sci. 2019 Aug 22;20(17):4101. doi: 10.3390/ijms20174101. Int J Mol Sci. 2019. PMID: 31443458 Free PMC article. Review.
Pharmacological Utilization of Bergamottin, Derived from Grapefruits, in Cancer Prevention and Therapy.
Ko JH, Arfuso F, Sethi G, Ahn KS. Ko JH, et al. Int J Mol Sci. 2018 Dec 14;19(12):4048. doi: 10.3390/ijms19124048. Int J Mol Sci. 2018. PMID: 30558157 Free PMC article. Review.
Neuroprotective Properties of Berberine: Molecular Mechanisms and Clinical Implications.
Tian E, Sharma G, Dai C. Tian E, et al. Antioxidants (Basel). 2023 Oct 19;12(10):1883. doi: 10.3390/antiox12101883. Antioxidants (Basel). 2023. PMID: 37891961 Free PMC article. Review.
Cancer metabolism and intervention therapy.
Zhao H, Li Y. Zhao H, et al. Mol Biomed. 2021 Feb 20;2(1):5. doi: 10.1186/s43556-020-00012-1. Mol Biomed. 2021. PMID: 35006438 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Affiliations

Targeting arachidonic acid pathway by natural products for cancer prevention and therapy

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials