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. 2015 Jan 5;5(1):1-9.
doi: 10.3390/diagnostics5010001.

Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

Hasan Onur Topçu  1 , Can Tekin İskender  2 , Ufuk Ceran  3 , Oktay Kaymak  4 , Hakan Timur  5 , Dilek Uygur  6 , Nuri Danışman  7
Affiliations

Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

Hasan Onur Topçu et al. Diagnostics (Basel). .

Abstract

We aimed to evaluate the diagnostic accuracy of serum D-dimer levels in pregnant women with adnexal torsion (AT). The pregnant women with ovarian cysts who suffered from pelvic pain were divided into two groups; the first group consisted of the cases with surgically proven as AT (n = 17) and the second group consisted of the cases whose pain were resolved in the course of follow-up period without required surgery (n = 34). The clinical characteristics and serum D-dimer levels were compared between the groups. Patients with AT had a higher rate of elevated serum white blood cell (WBC) count (57% vs. 16%, p = 0.04) and serum D-dimer levels (77% vs. 21%, p < 0.01) on admission in the study group than in the control group. Elevated D-dimer and cyst diameter larger than 5 cm yielded highest sensitivity (82% for each); whereas the presence of nausea and vomiting and elevated CRP had the highest specificity (85% and 88%, respectively). This is the first study that evaluates the serum D-dimer levels in humans in the diagnosis of AT, and our findings supported the use of D-dimer for the early diagnosis of AT in pregnant women.

Keywords: D-dimer; adnexal torsion; ovarian torsion; pregnancy.

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References

    1. Hasson J., Tsafrir Z., Azem F., Bar-On S., Almog B., Mashiach R., Seidman D., Lessing J.B., Grisaru D. Comparison of adnexal torsion between pregnant and nonpregnant women. Am. J. Obstet. Gynecol. 2010;202:536.e1–536.e6. - PubMed
    1. Koo Y.J., Kim T.J., Lee J.E., Kwon Y.S., Kim H.J., Lee I.H., Lim K.T., Lee K.H., Shim J.U., Mok J.E. Risk of torsion and malignancy by adnexal mass size in pregnant women. Acta Obstet. Gynecol. Scand. 2011;90:358–361. doi: 10.1111/j.1600-0412.2011.01070.x. - DOI - PubMed
    1. Huchon C., Staraci S., Fauconnier A. Adnexal torsion: A predictive score for pre-operative diagnosis. Hum. Reprod. 2010;25:2276–2280. doi: 10.1093/humrep/deq173. - DOI - PubMed
    1. Yen C.F., Lin S.L., Murk W., Wang C.J., Lee C.L., Soong Y.K., Arici A. Risk analysis of torsion and malignancy for adnexal masses during pregnancy. Fertil. Steril. 2009;91:1895–1902. doi: 10.1016/j.fertnstert.2008.02.014. - DOI - PubMed
    1. Murphy N., Broadhurst D., Khashan A., Gilligan O., Kenny L., O’Donoghue K. Gestation-specific D-dimer reference ranges: A cross-sectional study. BJOG. 2014 doi: 10.1111/1471-0528.12855. - DOI - PubMed

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