Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jun 1;1640(Pt A):130-138.
doi: 10.1016/j.brainres.2016.01.056. Epub 2016 Feb 8.

Brain stimulation: Neuromodulation as a potential treatment for motor recovery following traumatic brain injury

E Clayton  1 , S K Kinley-Cooper  1 , R A Weber  1 , D L Adkins  2
Affiliations
Review

Brain stimulation: Neuromodulation as a potential treatment for motor recovery following traumatic brain injury

E Clayton et al. Brain Res. .

Abstract

There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimulation efficacy derived from the stroke research field as proof of principle and then will review the few studies exploring neuromodulation in experimental TBI studies. This article is part of a Special Issue entitled SI:Brain injury and recovery.

Keywords: Epidural stimulation; Motor cortex; Rehabilitative training; Transcranial direct stimulation (tDCS); Transcranial stimulation (TMS).

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adkins DL, Voorhies AC, Jones TA. Behavioral and neuroplastic effects of focal endothelin–1 induced sensorimotor cortex lesions. Neuroscience. 2004;128:473–486. - PubMed
    1. Adkins DL, Campos P, Quach D, Borromeo M, Schallert K, Jones TA. Epidural cortical stimulation enhances motor function after sensorimotor cortical infarcts in rats. Exp Neurol. 2006;200:356–370. - PubMed
    1. Adkins DL, Hsu JE, Jones TA. Motor cortical stimulation promotes synaptic plasticity and behavioral improvements following sensorimotor cortex lesions. Exp Neurol. 2008;212:14–28. - PMC - PubMed
    1. Adkins DL. Cortical stimulation-induced structural plasticity and functional recovery in different models of brain injury. In: Kobeissy F, editor. Brain Neurotrauma Molecular, Neuropsychological, and Rehabilitation Aspects. Vol. 1. Taylor & Francis Group; 2015.
    1. Adkins DL, Ferguson L, Lance S, Pevtsov A, McDonough K, Stamschror J, Jones TA, Kozlowski DA. Combining multiple types of motor rehabilitation enhances skilled fore-limb use following experimental traumatic brain injury in rats. Neurorehabil Neural Repair 2015 - PMC - PubMed

Publication types

MeSH terms