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Case Reports
. 2016 Mar;31(1):121-4.
doi: 10.1007/s12291-015-0489-x. Epub 2015 Mar 14.

Hypogonadotropic Hypogonadism and Gynaecomastia in the Young Adult: A Case Series

Moushumi Lodh  1 , Rajarshi Mukhopadhyay  2
Affiliations
Case Reports

Hypogonadotropic Hypogonadism and Gynaecomastia in the Young Adult: A Case Series

Moushumi Lodh et al. Indian J Clin Biochem. 2016 Mar.

Abstract

We present three cases who presented to our Endocrinology OPD a few days apart with the common complaints of no or minimal development of secondary sexual characteristics. Although they had similar problems, investigations revealed a spectrum of different clinical, biochemical and genetic abnormalities. All the patients had otherwise normal anterior pituitary hormone secretion and sellar anatomy. One had a short Y chromosome, one was a Klinefelter syndrome and the other had no chromosomal abnormality. These findings along with absence of any detectable abnormality on pituitary imaging helped us diagnose these cases as Idiopathic hypogonadotropic hypogonadism. Treatment with testosterone showed marked improvement at 1 year follow up.

Keywords: Azoospermia; Endocrine system abnormalities; Gynaecomastia; Hypogonadism; Male infertility; Testosterone.

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Figures

Fig. 1
Fig. 1
Body habitus of the patients
Fig. 2
Fig. 2
X-ray wrist joint in second case
Fig. 3
Fig. 3
Short Y chromosome (marked by arrow)
See this image and copyright information in PMC

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