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. 1989 Oct;9(10):4571-5.
doi: 10.1128/mcb.9.10.4571-4575.1989.

Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae

J M Song  1 , S Picologlou, C M Grant, M Firoozan, M F Tuite, S Liebman
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Elongation factor EF-1 alpha gene dosage alters translational fidelity in Saccharomyces cerevisiae

J M Song et al. Mol Cell Biol. 1989 Oct.

Abstract

Changes in the dosage of genes encoding elongation factor EF-1 alpha were shown to cause parallel changes in the misreading of nonsense codons. Higher amounts of EF-1 alpha were correlated with increased nonsense suppression, suggesting that the level of EF-1 alpha is critically involved in translational fidelity.

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