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. 1989 Dec;9(12):5602-9.
doi: 10.1128/mcb.9.12.5602-5609.1989.

The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription

J S Fassler  1 , F Winston
Affiliations

The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription

J S Fassler et al. Mol Cell Biol. 1989 Dec.

Abstract

To understand the function of SPT13, a gene encoding a trans-acting factor involved in regulation of Ty-mediated gene expression, we have cloned and sequenced the gene. Our analysis revealed that SPT13 is the same gene as GAL11, a gene in which mutations cause reduced expression of some GAL4-regulated genes. Further analysis of spt13/gal11 mutants suggested that the SPT13 gene also affects transcription of genes involved in mating-type specialization. We show here that SPT13 has both positive and negative regulatory roles in transcription.

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