doi: 10.1128/mcb.9.12.5750-5753.1989.
The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation
Affiliations
- PMID: 2685576
- PMCID: PMC363751
- DOI: 10.1128/mcb.9.12.5750-5753.1989
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The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation
Mol Cell Biol.
1989 Dec.
Abstract
Monoclonal antibodies specific for the evolutionarily conserved C-terminal heptapeptide repeat domain of the largest subunit of RNA polymerase II inhibited the initiation of transcription from mammalian promoters in vitro. Since these antibodies did not inhibit elongation and randomly initiated transcription, the heptapeptide repeats may function by binding class II transcription initiation factor(s).
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