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. 1989 Dec;9(12):5750-3.
doi: 10.1128/mcb.9.12.5750-5753.1989.

The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation

M Moyle  1 , J S Lee, W F Anderson, C J Ingles
Affiliations

The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation

M Moyle et al. Mol Cell Biol. 1989 Dec.

Abstract

Monoclonal antibodies specific for the evolutionarily conserved C-terminal heptapeptide repeat domain of the largest subunit of RNA polymerase II inhibited the initiation of transcription from mammalian promoters in vitro. Since these antibodies did not inhibit elongation and randomly initiated transcription, the heptapeptide repeats may function by binding class II transcription initiation factor(s).

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References

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