The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation
- PMID: 2685576
- PMCID: PMC363751
- DOI: 10.1128/mcb.9.12.5750-5753.1989
The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation
Abstract
Monoclonal antibodies specific for the evolutionarily conserved C-terminal heptapeptide repeat domain of the largest subunit of RNA polymerase II inhibited the initiation of transcription from mammalian promoters in vitro. Since these antibodies did not inhibit elongation and randomly initiated transcription, the heptapeptide repeats may function by binding class II transcription initiation factor(s).
Similar articles
-
Inhibition of in vivo and in vitro transcription by monoclonal antibodies prepared against wheat germ RNA polymerase II that react with the heptapeptide repeat of eukaryotic RNA polymerase II.J Biol Chem. 1989 Jul 5;264(19):11511-20. J Biol Chem. 1989. PMID: 2472398
-
Transcription elongation factor SII interacts with a domain of the large subunit of human RNA polymerase II.Mol Cell Biol. 1988 Aug;8(8):3136-42. doi: 10.1128/mcb.8.8.3136-3142.1988. Mol Cell Biol. 1988. PMID: 3145407 Free PMC article.
-
The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II.Mol Cell Biol. 1992 May;12(5):2250-9. doi: 10.1128/mcb.12.5.2250-2259.1992. Mol Cell Biol. 1992. PMID: 1569952 Free PMC article.
-
Promoter specificity and modulation of RNA polymerase II transcription.FASEB J. 1989 Apr;3(6):1723-33. doi: 10.1096/fasebj.3.6.2649403. FASEB J. 1989. PMID: 2649403 Review.
-
The unique C-terminal domain of RNA polymerase II and its role in transcription.Adv Enzymol Relat Areas Mol Biol. 1995;71:41-77. doi: 10.1002/9780470123171.ch2. Adv Enzymol Relat Areas Mol Biol. 1995. PMID: 8644491 Review. No abstract available.
Cited by
-
RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chem Rev. 2013 Nov 13;113(11):8423-55. doi: 10.1021/cr400158h. Epub 2013 Sep 16. Chem Rev. 2013. PMID: 24040939 Free PMC article. Review. No abstract available.
-
Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II.Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2362-6. doi: 10.1073/pnas.91.6.2362. Proc Natl Acad Sci U S A. 1994. PMID: 8134400 Free PMC article.
-
Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD.RNA. 2002 Sep;8(9):1102-11. doi: 10.1017/s1355838202025037. RNA. 2002. PMID: 12358429 Free PMC article.
-
The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10004-8. doi: 10.1073/pnas.88.22.10004. Proc Natl Acad Sci U S A. 1991. PMID: 1946417 Free PMC article.
-
Tailored tails and transcription initiation: the carboxyl terminal domain of RNA polymerase II.Gene Expr. 1991 Apr;1(1):1-4. Gene Expr. 1991. PMID: 1820203 Free PMC article. Review. No abstract available.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases