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. 2016;21(4):347-52.
doi: 10.3109/1354750X.2016.1139183. Epub 2016 Feb 9.

XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Aaron J Specht  1 , Yanfen Lin  2 , Marc Weisskopf  3 , Chonghuai Yan  2 , Howard Hu  4 , Jian Xu  2 , Linda H Nie  1
Affiliations

XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning

Aaron J Specht et al. Biomarkers. 2016.

Abstract

Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.

Keywords: In vivo; X-ray fluorescence; portable.

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Figures

Figure 1
Figure 1
KXRF bone Pb versus blood Pb.
Figure 2
Figure 2
KXRF versus portable XRF bone lead.
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References

    1. Barry PS. A comparison of concentrations of lead in human tissues. Br J Ind Med. 1975;32:119–139. - PMC - PubMed
    1. Behinaein S, Chettle DR, Marro L, et al. Factors influencing uncertainties of in vivo bone lead measurement using a (109)Cd K X-ray fluorescence clover leaf geometry detector system. Environ Sci Process Impacts. 2014;16:2742–2751. - PubMed
    1. Bevington P, Robinson D. Data reduction and error analysis for the physical sciences. New York, NY: McGraw-Hill; 2003.
    1. Bleecker ML, McNeill F, Lindgren KN, et al. Relationship between bone lead and other indices of lead exposure in smelter workers. Toxicol Lett. 1995;77:241–248. - PubMed
    1. Canfield RL, Henderson CR, Cory-Slechta DA, et al. Intellectual impairment in children with blood lead concentrations below 10 µg per deciliter. N Engl J Med. 2003;348:26. - PMC - PubMed

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