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. 2016 Aug;37(8):10587-93.
doi: 10.1007/s13277-016-4954-9. Epub 2016 Feb 9.

Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway

Jun Li  1 , Zhangjun Song  2 , Yiyu Wang  3 , Yue Yin  3 , Ying Liu  3 , Rong Yuan  3 , Xing Nan  3
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Free article

Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway

Jun Li et al. Tumour Biol. 2016 Aug.
Free article

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Abstract

Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the molecular mechanism of SphK1 up-regulation in triple-negative breast cancer (TNBC) remains unclear. In this study, we assayed the expression level of SphK1 in TNBC tissues by qRT-PCR and immunohistochemistry. The level of S1P was quantified by ELISA in the serum of TNBC patients. Our results found that the levels of SphK1 and S1P were significantly increased in TNBC patients compared with normal control. Furthermore, knockdown of SphK1 with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion. These data suggest that SphK1 has an important role in TNBC and presents an attractive therapeutic target for the treatment for TNBC.

Keywords: AKT; Chemotherapy; PI3K; Sphingosine kinase 1; Sphingosine-1-phosphate; Triple-negative breast cancer.

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