CASP11 statistics and the prediction center evaluation system
- PMID: 26857434
- PMCID: PMC5479680
- DOI: 10.1002/prot.25005
CASP11 statistics and the prediction center evaluation system
Abstract
We outline the role of the Protein Structure Prediction Center (predictioncenter.org) in conducting the CASP11 and CASP ROLL experiments, discuss the experiment statistics, and provide an overview of the present CASP infrastructure. The biggest changes compared to the previous CASPs are the implementation of the evaluation system incorporating practically all evaluation measures, statistical tests, and visualization tools historically used by the CASP assessors, the expansion of the infrastructure to incorporate new categories of contact-assisted and multimeric predictions, and the redesign of the assessors' web-workspace enabling assessments based on multiple measures for different group categories and target sets. Proteins 2016; 84(Suppl 1):15-19. © 2016 Wiley Periodicals, Inc.
Keywords: CASP; protein structure modeling; protein structure prediction.
© 2016 Wiley Periodicals, Inc.
Similar articles
-
Evaluation of free modeling targets in CASP11 and ROLL.Proteins. 2016 Sep;84 Suppl 1(Suppl 1):51-66. doi: 10.1002/prot.24973. Epub 2016 Jan 20. Proteins. 2016. PMID: 26677002 Free PMC article.
-
CASP prediction center infrastructure and evaluation measures in CASP10 and CASP ROLL.Proteins. 2014 Feb;82 Suppl 2(0 2):7-13. doi: 10.1002/prot.24399. Epub 2013 Oct 18. Proteins. 2014. PMID: 24038551 Free PMC article.
-
Some of the most interesting CASP11 targets through the eyes of their authors.Proteins. 2016 Sep;84 Suppl 1(Suppl Suppl 1):34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16. Proteins. 2016. PMID: 26473983 Free PMC article.
-
The Need for Continuing Blinded Pose- and Activity Prediction Benchmarks.J Chem Inf Model. 2025 Mar 10;65(5):2180-2190. doi: 10.1021/acs.jcim.4c02296. Epub 2025 Feb 14. J Chem Inf Model. 2025. PMID: 39951479 Review.
-
Perspectives on Structural Molecular Biology Visualization: From Past to Present.J Mol Biol. 2018 Oct 19;430(21):3997-4012. doi: 10.1016/j.jmb.2018.07.009. Epub 2018 Jul 23. J Mol Biol. 2018. PMID: 30009769 Free PMC article. Review.
Cited by
-
Beyond sequence: Structure-based machine learning.Comput Struct Biotechnol J. 2022 Dec 29;21:630-643. doi: 10.1016/j.csbj.2022.12.039. eCollection 2023. Comput Struct Biotechnol J. 2022. PMID: 36659927 Free PMC article. Review.
-
Critical Assessment of Methods for Predicting the 3D Structure of Proteins and Protein Complexes.Annu Rev Biophys. 2023 May 9;52:183-206. doi: 10.1146/annurev-biophys-102622-084607. Epub 2023 Jan 10. Annu Rev Biophys. 2023. PMID: 36626764 Free PMC article. Review.
-
Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction (CASP14).Proteins. 2021 Dec;89(12):1673-1686. doi: 10.1002/prot.26172. Epub 2021 Jul 23. Proteins. 2021. PMID: 34240477 Free PMC article.
-
Protein structure prediction assisted with sparse NMR data in CASP13.Proteins. 2019 Dec;87(12):1315-1332. doi: 10.1002/prot.25837. Proteins. 2019. PMID: 31603581 Free PMC article.
-
Assessment of the Performances of the Protein Modeling Techniques Participating in CASP15 Using a Structure-Based Functional Site Prediction Approach: ResiRole.Bioengineering (Basel). 2023 Nov 30;10(12):1377. doi: 10.3390/bioengineering10121377. Bioengineering (Basel). 2023. PMID: 38135968 Free PMC article.
References
-
- Kryshtafovych A, Moult J, Basle A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T. Some of the most interesting CASP11 targets through the eyes of their authors. Proteins. 2015 - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources