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. 2016 Apr:57:74-9.
doi: 10.1016/j.pediatrneurol.2015.12.018. Epub 2016 Jan 7.

Maternal Infections During Pregnancy and Cerebral Palsy in the Child

Joshua J Bear  1 , Yvonne W Wu  2
Affiliations

Maternal Infections During Pregnancy and Cerebral Palsy in the Child

Joshua J Bear et al. Pediatr Neurol. 2016 Apr.

Abstract

Background: Chorioamnionitis is a risk factor for cerebral palsy. The relationship between extra-amniotic infections and cerebral palsy is less well studied. We examined maternal intra-amniotic and extra-amniotic infections and risk of cerebral palsy in the child.

Methods: Among a retrospective cohort of 6 million Californian births, 1991-2001, we analyzed administrative maternal and newborn hospital discharge abstracts linked to records of all children receiving services for cerebral palsy at the California Department of Developmental Services. We identified maternal hospital diagnoses of intra-amniotic (chorioamnionitis) and extra-amniotic (other genitourinary and respiratory) infections occurring up to 12 months before delivery. Using multivariable logistic regression, we determined the independent association between maternal infections and cerebral palsy, adjusting for infant sex, maternal age, race, education, socioeconomic status, and obesity.

Results: About 5.5% of mothers had a hospital discharge diagnosis of at least one of the following: chorioamnionitis (2.0%), other genitourinary (3.1%), and respiratory infection (0.6%). An infection diagnosis was more common in mothers of the 8473 infants with cerebral palsy than in mothers of unaffected children (13.7% vs 5.5%, P < 0.001). All three types of maternal infections (chorioamnionitis, odds ratio [OR] 3.1, 95% confidence interval [CI] 2.9-3.4; other genitourinary infection, OR 1.4, 95% CI 1.3-1.6; and respiratory infection, OR 1.9, 95% CI 1.5-2.2) were associated with cerebral palsy in multivariable analyses. Maternal extra-amniotic infections, whether diagnosed during prenatal or birth hospitalizations, conferred an increased risk of cerebral palsy.

Conclusions: Maternal extra-amniotic infections diagnosed in the hospital during pregnancy are associated with a modestly increased risk of cerebral palsy in the child.

Keywords: cerebral palsy; chorioamnionitis; epidemiology; neonatal neurology; prenatal infection.

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References

    1. Odding E, Roebroeck ME, Stam HJ. The epidemiology of cerebral palsy: incidence, impairments and risk factors. Disabil Rehabil. 2006;28(4):183–191. doi: 10.1080/09638280500158422. - DOI - PubMed
    1. Streja E, Miller JE, Bech BH, et al. Congenital cerebral palsy and prenatal exposure to self-reported maternal infections, fever, or smoking. American Journal of Obstetrics and Gynecology. 2013;209(4):332.e1–332.e10. doi: 10.1016/j.ajog.2013.06.023. - DOI - PMC - PubMed
    1. Himmelmann K, Uvebrant P. The panorama of cerebral palsy in Sweden. XI. Changing patterns in the birth-year period 2003-2006. Acta Paediatr. 2014 doi: 10.1111/apa.12614. n/a–n/a. - DOI - PubMed
    1. Winter S, Autry A, Boyle C, Yeargin-Allsopp M. Trends in the prevalence of cerebral palsy in a population-based study. Pediatrics. 2002;110(6):1220–1225. - PubMed
    1. Sellier E, Surman G, Himmelmann K, et al. Trends in prevalence of cerebral palsy in children born with a birthweight of 2,500 g or over in Europe from 1980 to 1998. Eur J Epidemiol. 2010;25(9):635–642. doi: 10.1007/s10654-010-9474-0. - DOI - PubMed

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