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. 2016 Sep;30(5):672-6.
doi: 10.1002/jcla.21920. Epub 2016 Feb 8.

Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

Mahmoud Ebrahimi  1 , Ali Reza Heidari-Bakavoli  1 , Sara Shoeibi  2 , Seyed Reza Mirhafez  3 , Mohsen Moohebati  1 , Habibollah Esmaily  4 , Hamed Ghazavi  2 , Maryam Saberi Karimian  5 , Seyed Mohammad Reza Parizadeh  6 , Maryam Mohammadi  6 , Hossein Mohaddes Ardabili  6 , Gordon A Ferns  7 , Majid Ghayour-Mobarhan  8   9
Affiliations

Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

Mahmoud Ebrahimi et al. J Clin Lab Anal. 2016 Sep.

Abstract

Background: Diabetes mellitus remains one of the major health problems of the 21st century and is associated with comorbidities including obesity and metabolic abnormalities. The study was conducted to evaluate serum high-sensitivity C-reactive protein (hs-CRP) levels, as a marker of inflammation, in a large sample of Iranian population without a history of cardiovascular or inflammatory disease and cancer, and to relate this to fasting blood glucose (FBG) and the presence of diabetes mellitus.

Methods: The study consisted of 7,762 subjects divided into four groups-nonobese/nondiabetic, obese/nondiabetic, nonobese/diabetic and obese/diabetic-based on the BMI classification and their FBG. Anthropometric characteristics were measured and blood was collected for the evaluation of fasted lipid profile, FBG and serum hs-CRP levels.

Results: Several clinical and biochemical characteristics were significantly different among the four groups: FBG, P < 0.001; total cholesterol (TC), P < 0.001; and triglyceride (TG), P < 0.001. The subjects with a serum hs-CRP >3 mg/dl had higher TC (P < 0.001), low-density lipoprotein cholesterol (LDL-C, P < 0.001), TG (P < 0.001), fat percentage (P < 0.001), and systolic and diastolic blood pressure (P < 0.001) compared with subjects with a serum hs-CRP <3 mg/dl. Multivariate analysis showed FBG, LDL-C, and waist circumference (WC) associated with increased serum hs-CRP levels (P < 0.001).

Conclusions: FBG, LDL-C, WC and gender are independently associated with serum hs-CRP concentrations.

Keywords: anthropometric characteristics; diabetes; high-sensitivity C-reactive protein (hs-CRP); obesity.

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Conflict of interest statement

The authors confirm no conflict of interest.

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