Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Feb 15;212(4):371-3.
doi: 10.1083/jcb.201601074. Epub 2016 Feb 8.

Muscle-on-chip: An in vitro model for donor-host cardiomyocyte coupling

Pieterjan Dierickx  1 , Linda W Van Laake  2
Affiliations
Comment

Muscle-on-chip: An in vitro model for donor-host cardiomyocyte coupling

Pieterjan Dierickx et al. J Cell Biol. .

Abstract

A key aspect of cardiac cell-based therapy is the proper integration of newly formed cardiomyocytes into the remnant myocardium after injury. In this issue, Aratyn-Schaus et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201508026) describe an in vitro model for heterogeneous cardiomyocyte coupling in which force transmission between cells can be measured.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
In vitro cardiomyocyte coupling model. (A) Neonatal cardiomyocytes (CMs) show greater contraction forces (arrows) than SC-CMs. Force generation at the lateral ends of the cells is depicted as a heat map. (B) Coupling of an immature SC-CM with a stronger nCM (bottom) results in extra focal adhesions (inset) compared with the homogeneous coupling of nCMs (top).
See this image and copyright information in PMC

Comment on

References

    1. Aratyn-Schaus Y., Pasqualini F.S., Yuan H., McCain M.L., Ye G.J.C., Sheehy S.P., Campbell P.H., and Parker K.K.. 2016. Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy. J. Cell Biol. 10.1083/jcb.201508026 - DOI - PMC - PubMed
    1. Bers D.M. 2001. Excitation-Contraction Coupling and Cardiac Contractile Force. Springer Netherlands, Dordrecht, Netherlands: 237 pp. 10.1007/978-94-010-0658-3 - DOI
    1. Birket M.J., Ribeiro M.C., Kosmidis G., Ward D., Leitoguinho A.R., van de Pol V., Dambrot C., Devalla H.D., Davis R.P., Mastroberardino P.G., et al. . 2015. Contractile defect caused by mutation in MYBPC3 revealed under conditions optimized for human PSC-cardiomyocyte function. Cell Reports. 13:733–745. 10.1016/j.celrep.2015.09.025 - DOI - PMC - PubMed
    1. Bolli R., Chugh A.R., D’Amario D., Loughran J.H., Stoddard M.F., Ikram S., Beache G.M., Wagner S.G., Leri A., Hosoda T., et al. . 2011. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 378:1847–1857. 10.1016/S0140-6736(11)61590-0 - DOI - PMC - PubMed
    1. Chong J.J.H., Yang X., Don C.W., Minami E., Liu Y.-W., Weyers J.J., Mahoney W.M., Van Biber B., Cook S.M., Palpant N.J., et al. . 2014. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 510:273–277. 10.1038/nature13233 - DOI - PMC - PubMed