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Comment
. 2016 Feb 15;212(4):371-3.
doi: 10.1083/jcb.201601074. Epub 2016 Feb 8.

Muscle-on-chip: An in vitro model for donor-host cardiomyocyte coupling

Pieterjan Dierickx  1 , Linda W Van Laake  2
Affiliations
Comment

Muscle-on-chip: An in vitro model for donor-host cardiomyocyte coupling

Pieterjan Dierickx et al. J Cell Biol. .

Abstract

A key aspect of cardiac cell-based therapy is the proper integration of newly formed cardiomyocytes into the remnant myocardium after injury. In this issue, Aratyn-Schaus et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201508026) describe an in vitro model for heterogeneous cardiomyocyte coupling in which force transmission between cells can be measured.

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Figures

Figure 1.
Figure 1.
In vitro cardiomyocyte coupling model. (A) Neonatal cardiomyocytes (CMs) show greater contraction forces (arrows) than SC-CMs. Force generation at the lateral ends of the cells is depicted as a heat map. (B) Coupling of an immature SC-CM with a stronger nCM (bottom) results in extra focal adhesions (inset) compared with the homogeneous coupling of nCMs (top).
See this image and copyright information in PMC

Comment on

References

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