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. 2016 Jan;23(1):15-23.
doi: 10.1016/j.sjbs.2015.01.017. Epub 2015 Feb 7.

Antioxidative and cytotoxic potential of some Chenopodium L. species growing in Poland

Renata Nowak  1 , Katarzyna Szewczyk  1 , Urszula Gawlik-Dziki  2 , Jolanta Rzymowska  3 , Łukasz Komsta  4
Affiliations

Antioxidative and cytotoxic potential of some Chenopodium L. species growing in Poland

Renata Nowak et al. Saudi J Biol Sci. 2016 Jan.

Abstract

The cytotoxic and antioxidant properties of lipophilic compounds extracted from different parts of four Chenopodium L. (Chenopodium album, Chenopodium hybridum, Chenopodium rubrum and Chenopodium urbicum) species were evaluated. The highest phenolic content was found in herb and seeds of all examined plants. Large amounts of free polyphenols were observed in herb extracts of C. album (3.36 mg/g DW), seeds of C. urbicum (3.87 mg/g DW) and roots of C. urbicum (1.52 mg/g DW). The cytotoxic activities of the extracts were assessed against human lung carcinoma A-549 and ovarian carcinoma TOV-112D and normal human fibroblast cell lines. Our study demonstrated that the extracts from the herb of C. rubrum and C. urbicum had the best antioxidant effect of all the extracts analyzed. Most of the extracts tested exhibited low cytotoxicity. However, the extracts from herb and seeds of C. album and C. hybridum showed the significant antiproliferative effect on the TOV-112 cell line. It can be concluded that antioxidant activity and phenolic composition differ mainly between plant parts and are quite similar between the plants, when the same plant part is analyzed. Thus, the Chenopodium extracts could be used as a readily accessible source of natural antioxidants, and may be used in the pharmaceutical industry and for food supplements production.

Keywords: Antioxidant activity; Chenopodium; Cytotoxic activity; Polyphenols.

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Figures

Figure 1
Figure 1
DPPH• radicals scavenging capacity of methanolic extracts from different parts of C. album, C.hybridum, C. rubrum and C. urbicum. CaR (C. album root); CrR (C. rubrum root); CaS (C. album seed); CaH (C. album herb); ChH (C. hybridum herb); CuH (C. urbicum herb); CrH (C. rubrum herb); CrS (C. rubrum seed); ChS (C. hybridum seed); CuS (C. urbicum seed); ChR (C. hybridum root); CuR (C. urbicum root). Bars having different letters are significantly different (p < 0.05).
Figure 2
Figure 2
Metal chelating activity of methanolic extracts from different parts of C. album, C. hybridum, C. rubrum and C. urbicum. Explanatory notes as in Fig 1. Bars having different letters are significantly different (p < 0.05).
Figure 3
Figure 3
Reducing power of methanolic extracts from different parts of C. album, C. hybridum, C. rubrum and C. urbicum. Explanatory notes as in Fig. 1. Bars having different letters are significantly different (p < 0.05).
Figure 4
Figure 4
Ability of lipid peroxidation inhibition of methanolic extracts from different parts of C. album, C. hybridum, C. rubrum and C. urbicum. Explanatory notes as in Fig. 1. Bars having different letters are significantly different (p < 0.05).
Figure 5
Figure 5
The score plot of the first two principal components of scaled PCA with corresponding loading vectors.
See this image and copyright information in PMC

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