Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015;14(3):172-6.

High Seroprevalence of Bordetella pertussis in Patients with Chronic Obstructive Pulmonary Disease: A Case-Control Study

Seyyed Hamid Hashemi  1 , Ebrahim Nadi  2 , Mehrdad Hajilooi  3 , Mohammad-Ali Seif-Rabiei  4 , Atefeh Samaei  4
Affiliations

High Seroprevalence of Bordetella pertussis in Patients with Chronic Obstructive Pulmonary Disease: A Case-Control Study

Seyyed Hamid Hashemi et al. Tanaffos. 2015.

Abstract

Background: Bordetella pertussis has been suggested to take part in the acute exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the association between B. pertussis and COPD.

Materials and methods: In this case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-B. pertussis IgG and IgA by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history and spirometric findings for each patient.

Results: Of 90 patients with chronic obstructive pulmonary disease, 66 (51%) had mild, 31 (34.4%) had moderate, and 13 (14.4%) had severe disease. There was no significant association between B. pertussis IgA seropositivity and COPD. Serum levels of anti- B. pertussis IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between B. pertussis infection and severity of COPD.

Conclusion: The results suggest that there is an association between B. pertussis infection and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms underlying these associations.

Keywords: Bordetella pertussis; Chronic Obstructive Pulmonary Disease; Whooping Cough.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Halperin SA. Pertussis and Other Bordetella Infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 17th ed New York: McGraw-Hill; 2012. p. 1241– 3.
    1. Waters V, Halperin SA. Bordetella pertussis. In: Bennett JE, Dolin R, Blaser MJ, editors. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition Philadelphia: Elsevier Health Sciences; 2015. P. 2619– 28.
    1. Park SJ, Lee YC, Rhee YK, Lee HB. Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in stable asthma and chronic obstructive pulmonary disease. J Korean Med Sci 2005; 20 (2): 225– 8. - PMC - PubMed
    1. Seemungal TA, Wedzicha JA, MacCallum PK, Johnston SL, Lambert PA. Chlamydia pneumoniae and COPD exacerbation. Thorax 2002; 57( 12): 1087– 8; author reply 1088–9. - PMC - PubMed
    1. Teramoto S. COPD pathogenesis from the viewpoint of risk factors. Intern Med 2007; 46 (2): 77– 9. - PubMed

LinkOut - more resources