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Review
. 2013 May 14;5(2-3):59-62.
doi: 10.3727/215517913X666558. eCollection 2013 Nov 10.

A Review of Autologous Islet Transplantation

Michihiro Maruyama  1 , Takashi Kenmochi  1 , Naotake Akutsu  1 , Kazunori Otsuki  1 , Taihei Ito  1 , Ikuko Matsumoto  1 , Takehide Asano  1
Affiliations
Review

A Review of Autologous Islet Transplantation

Michihiro Maruyama et al. Cell Med. .

Abstract

Autologous islet transplantation after total or semitotal pancreatectomy aims to preserve insulin secretory function and prevent the onset of diabetes. The major indication for pancreatectomy is chronic pancreatitis with severe abdominal pain, a benign pancreatic tumor, and trauma. The metabolic outcome of autologous islet transplantation is better than that of allogeneic transplantation and depends on the number of transplanted islets. Achieving islet isolation from a fibrous or damaged pancreas is one of the biggest challenges of autologous islet transplantation; a major complication is portal vein thrombosis after crude islet infusion. However, the incidence of portal vein thrombosis has decreased as islet preparation techniques have improved over time.

Keywords: Autologous transplantation; Islet; Total pancreatectomy.

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