Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug;7(4):303-12.
doi: 10.1007/s12975-016-0455-9. Epub 2016 Feb 10.

Strain-Related Differences in the Immune Response: Relevance to Human Stroke

Kyra J Becker  1
Affiliations
Review

Strain-Related Differences in the Immune Response: Relevance to Human Stroke

Kyra J Becker. Transl Stroke Res. 2016 Aug.

Abstract

There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.

Keywords: EAE; Immune response; Immunology; Strain; Stroke.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Temperatures after MCAO. Data are plotted as the mean (± standard deviation). Differences in temperature between vendors is assessed by ANOVA and noted by ‡ (P<0.001). Differences from baseline temperatures after MCAO among animals from a single vendor is assessed by paired t-test and noted by *(P<0.05) and **(P<0.01).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lartaud I, Bray-des-Boscs L, Chillon JM, Atkinson J, Capdeville-Atkinson C. In vivo cerebrovascular reactivity in Wistar and Fischer 344 rat strains during aging. Am J Physiol. 1993;264(3 Pt 2):H851–8. - PubMed
    1. Prieto R, Carceller F, Roda JM, Avendano C. The intraluminal thread model revisited: rat strain differences in local cerebral blood flow. Neurol Res. 2005;27(1):47–52. - PubMed
    1. Connolly ES, Jr., Winfree CJ, Stern DM, Solomon RA, Pinsky DJ. Procedural and strain-related variables significantly affect outcome in a murine model of focal cerebral ischemia. Neurosurgery. 1996;38(3):523–31. - PubMed
    1. Oliff HS, Weber E, Eilon G, Marek P. The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat. Brain Res. 1995;675(1-2):20–6. - PubMed
    1. Oliff HS, Weber E, Miyazaki B, Marek P. Infarct volume varies with rat strain and vendor in focal cerebral ischemia induced by transcranial middle cerebral artery occlusion. Brain Res. 1995;699(2):329–31. - PubMed

LinkOut - more resources