Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016;89(1060):20150830.
doi: 10.1259/bjr.20150830. Epub 2016 Feb 10.

Prospective evaluation of prostate with transrectal spectral Doppler with biopsy correlation: a clinicopathologic study

Syed M Danish Qaseem  1   2 , Nitin P Ghonge  3 , Bharat Aggarwal  4 , Sanjeev Singhal  5
Affiliations
Comparative Study

Prospective evaluation of prostate with transrectal spectral Doppler with biopsy correlation: a clinicopathologic study

Syed M Danish Qaseem et al. Br J Radiol. 2016.

Abstract

Objectives: To compare the transrectal (TR) spectral Doppler findings between benign prostatic hyperplasia group and prostate cancer group.

Methods: All the patients were assessed for adequate preparation, and informed consent was obtained prior to the procedure. The control group (n = 33) comprised patients who were negative for malignancy on biopsy. The study group (n = 22) were positive for malignancy and were also divided into three groups on the basis of the Gleason score. Study parameters included mean values for resistive index (RI), pulsatality index (PI), systolic/diastolic ratio (S/D) and peak systolic velocity (PSV). These were separately measured for bilateral capsular and urethral branches and compared between groups. In patients with unilateral tumour, these were compared between the tumour and non-tumour sides. Finally, the parameters were compared with patient's age. Mann-Whitney U test was used to evaluate the statistical significance.

Results: The mean values of RI, PI, S/D and PSV were found to be 0.84/1.03, 1.8/1.99, 3.93/4.45 and 15.52/16.15 cm s(-1), respectively, in the control and study groups which were not statistically significant. In patients with unilateral malignancy (n = 16), there was no significant difference from the non-tumour side. Doppler parameters showed statistically significant relationships with age. The mean of minimum RI was found to be 0.60 in patients less than 60 years of age and 0.76 in patients more than or equal to 60 years of age in the benign category (p-value = 0.014). The PI and S/D also showed significant difference in the benign category.

Conclusion: TR spectral Doppler parameters did not reveal any significant difference in patients with or without prostatic malignancy, irrespective of the Gleason grade. Doppler parameters, however, showed significant correlation with age and were lower in younger patients.

Advances in knowledge: TR spectral Doppler is unlikely to emerge as a diagnostic and prognostic tool for prostate carcinoma.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Method of obtaining Doppler indices from the right capsular artery. PI, pulsatality index; PSV, peak systolic velocity; RI, resistive index; S/D, systolic/diastolic ratio.
Figure 2.
Figure 2.
Method of obtaining Doppler indices from the left capsular artery. PI, pulsatality index; PSV, peak systolic velocity; RI, resistive index; S/D, systolic/diastolic ratio.
Figure 3.
Figure 3.
Method of obtaining Doppler indices from the right urethral artery. PI, pulsatality index; PSV, peak systolic velocity; RI, resistive index; S/D, systolic/diastolic ratio.
Figure 4.
Figure 4.
Method of obtaining Doppler indices from the left urethral artery. PI, pulsatality index; PSV, peak systolic velocity; RI, resistive index; S/D, systolic/diastolic ratio.
See this image and copyright information in PMC

References

    1. Rifkin MD, Sudakoff GS, Alexander AA. Prostate: techniques, results, and potential applications of color Doppler US scanning. Radiology 1993; 186: 509–13. doi: 10.1148/radiology.186.2.7678467 - DOI - PubMed
    1. Louvar E, Littrup PJ, Goldstein A, Yu L, Grignon SW. Correlation of color Doppler flow in the prostate with tissue microvascularity. Cancer 1998; 83: 135–40. doi: 10.1002/(SICI)1097-0142(19980701)83:1<135::AID-CNCR18>3.0.CO;2-Y - DOI - PubMed
    1. Neumaier CE, Martinoli C, Derchi LE, Silvestri E, Rosenberg I. Normal prostate gland: examination with color Doppler US. Radiology 1995; 196: 453–7. doi: 10.1148/radiology.196.2.7617860 - DOI - PubMed
    1. Huang ST, Hsieh ML. Evaluation of resistance index in patients with prostate cancer. Anticancer Res 2008; 28: 1985–8. - PubMed
    1. Turgut AT, Ölçücüoglu E, Kosar P, Geyik PO, Kosar U, Dogra V. Power Doppler ultrasonography of the feeding arteries of the prostate gland: a novel approach to the diagnosis of prostate cancer? J Ultrasound Med 2007; 26: 875–83. - PubMed