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. 1977 Jul;74(7):2720-4.
doi: 10.1073/pnas.74.7.2720.

A DNA fragment containing the origin of replication of the Escherichia coli chromosome

R C Marsh, A Worcel

A DNA fragment containing the origin of replication of the Escherichia coli chromosome

R C Marsh et al. Proc Natl Acad Sci U S A. 1977 Jul.

Abstract

A 38 kilobase pair region of the Escherichia coli K12 chromosome containing the replication origin has been physically mapped with restriction endonucleases EcoRI and HindIII. Replication starts within or very near a 1.3 kilobase pair HindIII fragment in the middle of this region and proceeds outward in both directions with apparently equal speed. This pattern was observed in both dnaA and dnaC temperature-sensitive (ts) initiation mutants at the start of the synchronous round of replication which occurs after downshift from the nonpermissive to the permissive temperature.

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References

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