Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Feb 16;113(7):1692-4.
doi: 10.1073/pnas.1600097113. Epub 2016 Feb 9.

Reservoir expansion by T-cell proliferation may be another barrier to curing HIV infection

Michelle Kim  1 , Robert F Siliciano  2
Affiliations
Comment

Reservoir expansion by T-cell proliferation may be another barrier to curing HIV infection

Michelle Kim et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Possible causes of clonal expansion of infected CD4+ T cells. Uninfected CD4+ T cells (in grayscale) circulate with rare CD4+ T cells that carry an integrated HIV-1 provirus (various colors). CD4+ T lymphocytes can undergo clonal expansion as a result of (A) homeostatic proliferation, (B) interaction with antigen from antigen presenting cell (in black), or (C) altered expression of host genes affecting cell growth because of effects of proviral integration into these genes.
See this image and copyright information in PMC

Comment on

  • Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.
    Simonetti FR, Sobolewski MD, Fyne E, Shao W, Spindler J, Hattori J, Anderson EM, Watters SA, Hill S, Wu X, Wells D, Su L, Luke BT, Halvas EK, Besson G, Penrose KJ, Yang Z, Kwan RW, Van Waes C, Uldrick T, Citrin DE, Kovacs J, Polis MA, Rehm CA, Gorelick R, Piatak M, Keele BF, Kearney MF, Coffin JM, Hughes SH, Mellors JW, Maldarelli F. Simonetti FR, et al. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1883-8. doi: 10.1073/pnas.1522675113. Epub 2016 Feb 8. Proc Natl Acad Sci U S A. 2016. PMID: 26858442 Free PMC article.

References

    1. Finzi D, et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med. 1999;5(5):512–517. - PubMed
    1. Crooks AM, et al. Precise quantitation of the latent HIV-1 reservoir: Implications for eradication strategies. J Infect Dis. 2015;212(9):1361–1365. - PMC - PubMed
    1. Simonetti FR, et al. Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo. Proc Natl Acad Sci USA. 2016;113:1883–1888. - PMC - PubMed
    1. Günthard HF, et al. International Antiviral Society-USA Panel Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014;312(4):410–425. - PubMed
    1. Maldarelli F, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science. 2014;345(6193):179–183. - PMC - PubMed

Publication types

LinkOut - more resources