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Review
. 2016;89(1061):20151030.
doi: 10.1259/bjr.20151030. Epub 2016 Feb 11.

Imaging genomics in cancer research: limitations and promises

Harrison X Bai  1 , Ashley M Lee  1 , Li Yang  2 , Paul Zhang  3 , Christos Davatzikos  1 , John M Maris  4   5   6 , Sharon J Diskin  4   5   6
Affiliations
Review

Imaging genomics in cancer research: limitations and promises

Harrison X Bai et al. Br J Radiol. 2016.

Abstract

Recently, radiogenomics or imaging genomics has emerged as a novel high-throughput method of associating imaging features with genomic data. Radiogenomics has the potential to provide comprehensive intratumour, intertumour and peritumour information non-invasively. This review article summarizes the current state of radiogenomic research in tumour characterization, discusses some of its limitations and promises and projects its future directions. Semi-radiogenomic studies that relate specific gene expressions to imaging features will also be briefly reviewed.

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Figures

Figure 1.
Figure 1.
Literature search of published studies on radiogenomics.
Figure 2.
Figure 2.
Ideal design for a radiogenomic study. CGH, comparative genomic hybridization; CHIP, chromatin immunoprecipitation; OS, overall survival; PET, positron emission tomography; PFS, progression-free survival; SNP, single nucleotide polymorphism.
See this image and copyright information in PMC

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