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Comparative Study
. 2016 Jun;46(6):2088-2099.
doi: 10.1007/s10803-016-2737-1.

Infant Development in Fragile X Syndrome: Cross-Syndrome Comparisons

Jane E Roberts  1 , Lindsay M McCary  2   3 , Svetlana V Shinkareva  2 , Donald B Bailey Jr  4
Affiliations
Comparative Study

Infant Development in Fragile X Syndrome: Cross-Syndrome Comparisons

Jane E Roberts et al. J Autism Dev Disord. 2016 Jun.

Abstract

This study examined the developmental profile of male infants with fragile X syndrome (FXS) and its divergence from typical development and development of infants at high risk for autism associated with familial recurrence (ASIBs). Participants included 174 boys ranging in age from 5 to 28 months. Cross-sectional profiles on the Mullen Scales of Early Learning indicated infants with FXS could be differentiated from typically developing infants and ASIBs by 6 months of age. Infants with FXS displayed a trend of lower developmental skills with increasing age that was unique from the typically developing and ASIB groups. Findings suggest infants with FXS present with more significant, pervasive and early emerging delays than previously reported with potentially etiologically distinct developmental profiles.

Keywords: Autism; Early development; Fragile X syndrome; Infants; Mullen.

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Linear Regression Models for the Four Domain Scores
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References

    1. Bailey DB, Jr, Hatton DD, Mesibov G, Ament N, Skinner M. Early development, temperament, and functional impairment in autism and fragile X syndrome. Journal of Autism and Developmental Disorders. 2000;30:557–567. - PubMed
    1. Bailey DB, Jr, Hatton DD, Skinner M. Early developmental trajectories of males with fragile X syndrome. American Journal on Mental Retardation. 1998;103(1):29–39. - PubMed
    1. Bailey DB, Jr, Raspa M, Bishop E, Holiday D. No change in the age of diagnosis for FXS: Findings from a national parent survey. Pediatrics. 2009;142 - PubMed
    1. Bailey DB, Raspa M, Olmsted M, Holiday DB. Co-occurring conditions associated with FMR1 gene variations: Findings from a national parent survey. American Journal of Medical Genetics Part A. 2008;146(16):2060–2069. - PubMed
    1. Bayley N. Bayley scales of infant development: Manual. Psychological Corporation; 1993.

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