Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Jun;46(6):2088-2099.
doi: 10.1007/s10803-016-2737-1.

Infant Development in Fragile X Syndrome: Cross-Syndrome Comparisons

Jane E Roberts  1 , Lindsay M McCary  2   3 , Svetlana V Shinkareva  2 , Donald B Bailey Jr  4
Affiliations
Comparative Study

Infant Development in Fragile X Syndrome: Cross-Syndrome Comparisons

Jane E Roberts et al. J Autism Dev Disord. 2016 Jun.

Abstract

This study examined the developmental profile of male infants with fragile X syndrome (FXS) and its divergence from typical development and development of infants at high risk for autism associated with familial recurrence (ASIBs). Participants included 174 boys ranging in age from 5 to 28 months. Cross-sectional profiles on the Mullen Scales of Early Learning indicated infants with FXS could be differentiated from typically developing infants and ASIBs by 6 months of age. Infants with FXS displayed a trend of lower developmental skills with increasing age that was unique from the typically developing and ASIB groups. Findings suggest infants with FXS present with more significant, pervasive and early emerging delays than previously reported with potentially etiologically distinct developmental profiles.

Keywords: Autism; Early development; Fragile X syndrome; Infants; Mullen.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Linear Regression Models for the Four Domain Scores
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bailey DB, Jr, Hatton DD, Mesibov G, Ament N, Skinner M. Early development, temperament, and functional impairment in autism and fragile X syndrome. Journal of Autism and Developmental Disorders. 2000;30:557–567. - PubMed
    1. Bailey DB, Jr, Hatton DD, Skinner M. Early developmental trajectories of males with fragile X syndrome. American Journal on Mental Retardation. 1998;103(1):29–39. - PubMed
    1. Bailey DB, Jr, Raspa M, Bishop E, Holiday D. No change in the age of diagnosis for FXS: Findings from a national parent survey. Pediatrics. 2009;142 - PubMed
    1. Bailey DB, Raspa M, Olmsted M, Holiday DB. Co-occurring conditions associated with FMR1 gene variations: Findings from a national parent survey. American Journal of Medical Genetics Part A. 2008;146(16):2060–2069. - PubMed
    1. Bayley N. Bayley scales of infant development: Manual. Psychological Corporation; 1993.

Publication types

MeSH terms