Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2016 May;63(5):887-92.
doi: 10.1002/pbc.25915. Epub 2016 Jan 27.

Chemotherapy-Induced Nausea and Vomiting Prophylaxis: Practice Within the Children's Oncology Group

Priya Patel  1 , Paula D Robinson  2 , Andrea Orsey  3   4 , Jason L Freedman  5   6 , Anne-Marie Langevin  7 , Debbie Woods  8 , Lillian Sung  9   10 , L Lee Dupuis  1   9   11
Affiliations
Clinical Trial

Chemotherapy-Induced Nausea and Vomiting Prophylaxis: Practice Within the Children's Oncology Group

Priya Patel et al. Pediatr Blood Cancer. 2016 May.

Abstract

Background: The Children's Oncology Group (COG) has endorsed a clinical practice guideline (CPG) for acute chemotherapy-induced nausea and vomiting (CINV) prophylaxis in children with cancer. This project aims to describe current acute CINV prophylaxis practice at COG sites and the gap between this practice and CPG recommendations.

Procedure: Two surveys were developed. The first survey, sent to 94 cancer control and supportive care responsible individuals (CCL RIs) at 94 COG institutions, asked if the institution had a standardized approach to practice and focused on antiemetic agent choice. The second survey, sent to 54 pharmacists at COG sites where the CCL RI indicated that there was a standardized approach to CINV prophylaxis practice, focused on antiemetic dosing. Survey results were described and analyzed for consistency with the CPG recommendations.

Results: Among the 69 respondents to the first survey, 54 (78%) stated that their institutions have a standardized approach to CINV prophylaxis practice. However, antiemetic choice varied widely among respondents. Results from the 36 respondents to the second survey also demonstrated significant antiemetic dosing practice variability. Frequent sources of deviation from CPG recommendations were as follows: antiemetic choice when corticosteroids are contraindicated, dexamethasone dosing, aprepitant use in children less than 12 years, and aprepitant use in the presence of a known or suspected drug interaction.

Conclusions: There is a great diversity in the CINV prophylaxis provided to children with cancer at COG sites. Concerted strategies are required to improve awareness of the current CINV prophylaxis CPG and to facilitate CPG-consistent CINV prophylaxis.

Keywords: antiemetic; chemotherapy-induced vomiting; nausea; pediatrics; supportive care; vomiting.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Statement: There are no conflicts of interest.

References

    1. Dupuis LL, Milne-Wren C, Cassidy M, Barrera M, Portwine C, Johnston D, Silva M, Sibbald C, Leaker M, Routh S, Sung L. Symptom assessment in children receiving cancer therapy: the parents’ perspective. Support Care Cancer. 2010;18(3):281–299. - PubMed
    1. Rodgers C, Kollar D, Taylor O, Bryant R, Crockett K, Gregurich MA, Hockenberry M. Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment. Cancer Nurs. 2012;35(3):203–210. - PubMed
    1. Rodgers C, Norville R, Taylor O, Poon C, Hesselgrave J, Gregurich MA, Hockenberry M. Children’s coping strategies for chemotherapy-induced nausea and vomiting. Oncol Nurs Forum. 2012;39(2):202–209. - PubMed
    1. Aapro M, Molassiotis A, Dicato M, Pelaez I, Rodriguez-Lescure A, Pastorelli D, Ma L, Burke T, Gu A, Gascon P, Roila F investigators P. The effect of guideline-consistent antiemetic therapy on chemotherapy-induced nausea and vomiting (CINV): the Pan European Emesis Registry (PEER) Ann Oncol. 2012;23(8):1986–1992. - PubMed
    1. Gilmore JW, Peacock NW, Gu A, Szabo S, Rammage M, Sharpe J, Haislip ST, Perry T, Boozan TL, Meador K, Cao X, Burke TA. Antiemetic guideline consistency and incidence of chemotherapy-induced nausea and vomiting in US community oncology practice: INSPIRE Study. J Oncol Pract. 2014;10(1):68–74. - PubMed