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. 2015;59(10-12):471-8.
doi: 10.1387/ijdb.150192ao.

Expression of Sox genes in tooth development

Katsushige Kawasaki  1 , Maiko Kawasaki, Momoko Watanabe, Erik Idrus, Takahiro Nagai, Shelly Oommen, Takeyasu Maeda, Nobuko Hagiwara, Jianwen Que, Paul T Sharpe, Atsushi Ohazama
Affiliations

Expression of Sox genes in tooth development

Katsushige Kawasaki et al. Int J Dev Biol. 2015.

Abstract

Members of the Sox gene family play roles in many biological processes including organogenesis. We carried out comparative in situ hybridization analysis of seventeen sox genes (Sox1-14, 17, 18, 21) during murine odontogenesis from the epithelial thickening to the cytodifferentiation stages. Localized expression of five Sox genes (Sox6, 9, 13, 14 and 21) was observed in tooth bud epithelium. Sox13 showed restricted expression in the primary enamel knots. At the early bell stage, three Sox genes (Sox8, 11, 17 and 21) were expressed in pre-ameloblasts, whereas two others (Sox5 and 18) showed expression in odontoblasts. Sox genes thus showed a dynamic spatio-temporal expression during tooth development.

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Figures

Fig. 1
Fig. 1. The expression of Sox genes (Group B) in rodent tooth development
In situ hybridisation of Sox1, Sox2, Sox3, Sox14 and Sox21 on frontal head sections at E10.5, E11.5, E13.5, E14.5 and E18.5. Tooth epithelium is outlined in red. Arrowheads indicate the presumptive tooth region.
Fig. 2
Fig. 2. The expression of Sox genes (Group C) in rodent tooth development
In situ hybridisation of Sox4, Sox11 and Sox12 on frontal head sections at E10.5, E11.5, E13.5, E14.5 and E18.5. Tooth epithelium is outlined in red. Arrowheads indicate the presumptive tooth region. Arrow indicates the presumptive alveolar bone region.
Fig. 3
Fig. 3. The expression of Sox genes (Group D) in rodent tooth development
In situ hybridisation of Sox5, Sox6 and Sox13 on frontal head sections at E10.5, E11.5, E13.5, E14.5 and E18.5. Tooth epithelium is outlined in red. Arrowheads indicate the presumptive tooth region.
Fig. 4
Fig. 4. The expression of Sox genes (Group E) in rodent tooth development
In situ hybridisation of Sox8, Sox9 and Sox10 on frontal head sections at E10.5, E11.5, E13.5, E14.5 and E18.5. Tooth epithelium is outlined in red. Arrowheads indicate the presumptive tooth region.
Fig. 5
Fig. 5. The expression of Sox genes (Group F) in rodent tooth development
In situ hybridisation of Sox7, Sox17 and Sox18 on frontal head sections at E10.5, E11.5, E13.5, E14.5 and E18.5. Tooth epithelium is outlined in red. Arrowheads indicate the presumptive tooth region.
Fig. 6
Fig. 6. Molar tooth phenotypes in Sox2fl/fl;K14Cre, Krt5-Cre;Rosa26Sox2/+ and Sox6 mutant mice
Frontal sections showing the first lower molars of WT (A), Sox2fl/fl;K14Cre (B), Krt5Cre;Rosa26Sox2/+ (C) and Sox6 (D) mice at E18.5.
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