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. 1977 Jul;74(7):3035-7.
doi: 10.1073/pnas.74.7.3035.

Cholecystokinin and its COOH-terminal octapeptide in the pig brain

J E Muller, E Straus, R S Yalow

Cholecystokinin and its COOH-terminal octapeptide in the pig brain

J E Muller et al. Proc Natl Acad Sci U S A. 1977 Jul.

Abstract

Two components--one resembling intact cholecystokinin in size and charge and immunologic specificity, and the other resembling the COOH-terminal octapeptide of cholecystokinin--have been found in extracts of the pig cerebral cortex. The relative concentrations of the two peptides in the extracts were dependent on the extractant, boiling 0.1 M HCl being more effective than boiling water for the extraction of intact cholecystokinin but less effective for the extraction of the octapeptide. The physiologic role of these peptides in the brain has yet to be elucidated.

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References

    1. Science. 1964 Jun 12;144(3624):1344-6 - PubMed
    1. N Engl J Med. 1977 Feb 3;296(5):266-71 - PubMed
    1. Nature. 1976 Dec 9;264(5586):568-70 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Jul;74(7):3033-4 - PubMed
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