Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Yu Fu¹, Inhan Lee², Yong Sun Lee³, Xiaoyong Bao⁴

Affiliations

¹ Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
² miRcore, Ann Arbor, MI 48105, USA.
³ Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
⁴ Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute of Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.

PMID: 26865839
PMCID: PMC4742329
DOI: 10.5808/GI.2015.13.4.94

Review

Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

Yu Fu et al. Genomics Inform. 2015 Dec.

. 2015 Dec;13(4):94-101.

doi: 10.5808/GI.2015.13.4.94. Epub 2015 Dec 31.

Authors

Yu Fu¹, Inhan Lee², Yong Sun Lee³, Xiaoyong Bao⁴

Affiliations

¹ Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.
² miRcore, Ann Arbor, MI 48105, USA.
³ Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
⁴ Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA.; Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute of Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.; The Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.

PMID: 26865839
PMCID: PMC4742329
DOI: 10.5808/GI.2015.13.4.94

Abstract

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.

Keywords: RSV replication, tRNA, tRNA-derived RNA fragments; neoplasms; neurodegenerative diseases.

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Figures

**Fig. 1. tRNA processing and classification of tRNA-derived RNA fragments (tRFs).**

**Fig. 2. Biological roles of tRNA-derived RNA fragments (tRFs).**

See this image and copyright information in PMC

References

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1. Lee YS, Shibata Y, Malhotra A, Dutta A. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs) Genes Dev. 2009;23:2639–2649. - PMC - PubMed
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

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