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. 2016 Feb 10:20:1.
doi: 10.1186/s40824-016-0048-4. eCollection 2016.

Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

Gyeong-Hyeon Gwak  1 , Ae-Jin Choi  2 , Yeoung-Seuk Bae  2 , Hyun-Jin Choi  2 , Jae-Min Oh  1
Affiliations

Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

Gyeong-Hyeon Gwak et al. Biomater Res. .

Abstract

Background: In order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we prepared biopolymer/ceramic hybrids consisting of various natural biopolymers and layered double hydroxide (LDH) ceramic nanoparticles via an electrophoretic method. We studied the structures and controlled-release properties of these materials.

Results and discussion: X-ray diffraction (XRD) patterns and X-ray absorption spectra (XAS) showed that LDH nanoparticles were formed in a biopolymer hydrogel through electrophoretic reaction. Scanning electron microscopic (SEM) images showed that the ceramic nanoparticles were homogeneously distributed throughout the hydrogel matrix. An antioxidant agent (i.e., ferulic acid) was loaded onto agarose/LDH and gelatin/LDH hybrids, and the time-dependent release of ferulic acid was investigated via high-performance liquid chromatography (HPLC) for kinetic model fitting.

Conclusions: Biopolymer/LDH hybrid materials that were prepared by electrophoretic method created a homogeneous composite of two components and possessed controllable drug release properties according to the type of biopolymer.

Keywords: Agarose; Biopolymer; Ceramic; Controlled release; Electrophoretic synthesis; Gelatin; Layered double hydroxide.

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Figures

Scheme 1
Scheme 1
Schematic molecular structures of biopolymers and LDH nanoparticles
Fig. 1
Fig. 1
XRD patterns of (a) agarose film, (b) agarose/LDH, (c) gelatin, (d) gelatin/LDH, and (e) coprecipitated ZnAl-LDH nanoparticles
Fig. 2
Fig. 2
a Zn K-edge XANES spectra and b Fourier-transformed EXAFS spectra for (a) coprecipitated ZnAl-LDH nanoparticles and (b) agarose/LDH
Fig. 3
Fig. 3
FE-SEM images of (a), (b) coprecipitated ZnAl-LDH and (c), (d) agarose/LDH
Fig. 4
Fig. 4
a Time-dependent ferulic acid release patterns from agarose/LDH (open circle) and gelatin/LDH (open square) and b their kinetic model fitting results and kinetic constants
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