Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Feb 11;12(2):e1005355.
doi: 10.1371/journal.ppat.1005355. eCollection 2016 Feb.

The March towards a Vaccine for Congenital CMV: Rationale and Models

Kristy M Bialas  1 , Sallie R Permar  1   2
Affiliations

The March towards a Vaccine for Congenital CMV: Rationale and Models

Kristy M Bialas et al. PLoS Pathog. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Virus transmission and pregnancy outcome in a novel nonhuman primate model of congenital rhCMV infection.
(A) The rate of congenital rhCMV transmission in CD4 T cell depleted (red, CD4-) and nondepleted (blue, CD4+) dams following primary maternal rhCMV infection was determined by detection of rhCMV DNA in amniotic fluid (AF) using quantitative PCR. Peak AF viral loads and mean copy number for CD4- and CD4+ females are shown. (B) Percent survival of fetuses following maternal rhCMV inoculation.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Schleiss M. R., and Heineman T. C. 2005. Progress toward an elusive goal: current status of cytomegalovirus vaccines. Expert Rev Vaccines 4:381–406. - PubMed
    1. Boppana S. B., Ross S. A., and Fowler K. B. 2013. Congenital cytomegalovirus infection: clinical outcome. Clin Infect Dis 57: Suppl 4 S178–S181. 10.1093/cid/cit629 - DOI - PMC - PubMed
    1. Lilleri D., Fornara C., Furione M., Zavattoni M., Revello M.G., and Gerna G. 2007. Development of human cytomegalovirus-specific T cell immunity during primary infection of pregnant women and its correlation with virus transmission to the fetus. J Infect Dis 195: 1062–1070. 10.1086/512245 - DOI - PubMed
    1. Boppana S. B. and Britt W. J. 1995. Antiviral antibody responses and intrauterine transmission after primary maternal cytomegalovirus infection. J Infect Dis 171:1115–1121. 10.1093/infdis/171.5.1115 - DOI - PubMed
    1. Lilleri D., Kabanova A., Revello M. G., Percivalle E., Sarasini A., Genini E, Sallusto F., Lanzavecchia A., Corti D. and Gerna G. 2013. Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection. PLoS ONE. 8:e59863 10.1371/journal.pone.0059863 - DOI - PMC - PubMed

Publication types

Substances