Review
doi: 10.1016/j.brainres.2016.02.003.
Epub 2016 Feb 8.
The long pursued Holy Grail of the true "alcoholic" rat
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- PMID: 26867703
- DOI: 10.1016/j.brainres.2016.02.003
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Review
The long pursued Holy Grail of the true "alcoholic" rat
Brain Res.
.
Abstract
An anthology of microdialysis and electrophysiological studies on ethanol effect on mesolimbic dopaminergic neurons is presented. The usefulness of rats with innate preference for ethanol, such as the Sardinian alcohol-preferring (sP), in studying ethanol rewarding and reinforcing effects is signaled. The generation of the long sought "alcoholics rat" from sP rats is announced. Rats of the sP line avoid the shortcomings of using rats non selected for ethanol preference.
Keywords: Addiction; Dopamine; Electrophysiology; Ethanol; Sardinian alcohol-preferring rats; Ventral tegmental area.
Copyright © 2016. Published by Elsevier B.V.
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