[In vivo sensitivity of Plasmodium falciparum to piperaquine phosphate assayed in Linshui and Baisha counties, Hainan Province]
[Article in
Chinese]
- PMID: 2686856
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[In vivo sensitivity of Plasmodium falciparum to piperaquine phosphate assayed in Linshui and Baisha counties, Hainan Province]
[Article in
Chinese]
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi.
1989.
Abstract
Fifty-three cases of falciparum malaria in Linshui County, Baisha County and Sanya Municipality were treated with piperaquine phosphate at a total dose of 1.5g base over 3 days in July to December, 1986. The mean defervescence time was 36 +/- 20.7h; the mean asexual parasite clearance time was 69.7 +/- 20.9h. At 14-28d follow-up recrudescence was observed with asexual parasitemia in 7 of the 47 cases, showing RI resistance to piperaquine. Gametocytemia was positive in 35 cases (74.5%) during the follow-up period.
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