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. 2016 Jul;29(7):814-20.
doi: 10.1093/ajh/hpw007. Epub 2016 Feb 11.

Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study

Steven R Horbal  1 , William Seffens  2 , Adam R Davis  3 , Natalia Silvestrov  2 , Gary H Gibbons  4 , Rakale C Quarells  2 , Aurelian Bidulescu  5
Affiliations

Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study

Steven R Horbal et al. Am J Hypertens. 2016 Jul.

Abstract

Background: Apelin is an adipokine directly associated with adiposity, insulin resistance, and decreased blood pressure. Urinary 8-isoprostane is a marker of chronic oxidative endothelial stress. Visfatin, an adipokine that acts by binding and activating the insulin receptor, has been associated with hypertension. As severe hypertension (SH) is highly prevalent among African Americans (AA), we aimed to assess the association of these biomarkers with SH status.

Methods: A sample of 250 AA participants (134 normotensive controls and 116 with SH (including 98 treatment controlled, SCH: severe controlled hypertension, and 18 treatment resistant, SRH: severe resistant hypertension)) from the Minority Health Genomics and Translational Research Bio-Repository Database (MH-GRID) in metro Atlanta had blood analyzed for apelin and visfatin and urine for 8-isoprostane. T-tests, sex-specific age-adjusted correlation coefficients, and multivariable logistic regression models were used to assess the association of biomarkers with hypertensive status.

Results: Levels of apelin and 8-isoprostane were not statistically different between controls and SCH or SRH. Statistically significant differences were present in levels of visfatin between controls (1.03±0.84 pg/ml), SCH (1.34±1.14 pg/ml), and SRH (1.59±0.85 pg/ml). After multivariable adjustment, categorization in the middle 2 quartiles of urinary 8-isoprostane were associated with SH. In similar models, categorization into the highest quartile of visfatin was associated with SH (odds ratio = 2.80; 95% confidence interval: 1.02-7.02). A continuous association of visfatin with SH was present.

Conclusion: In our community sample of AA, there were increased odds of SH with increased levels of urinary 8-isoprostane and visfatin, but not with apelin.

Keywords: African Americans; adipokines; apelin; blood pressure; hypertension; severe hypertension; urinary 8-isoprostane; visfatin..

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References

    1. Flack JM, Ferdinand KC, Nasser SA . Epidemiology of hypertension and cardiovascular disease in African Americans . J Clin Hypertens (Greenwich) 2003. ; 5 ( 1 Suppl 1 ): 5 – 11 . - PMC - PubMed
    1. Nwankwo T, Yoon SS, Burt V, Gu Q. Hypertension Among Adults in the United States: National Health and Nutrition Examination Survey, 2011–2012 (Internet) . Center for Disease Control and Prevention; . http://www.cdc.gov/nchs/data/databriefs/db133.htm . 2013. . Accessed 3 September 2015.
    1. Calhoun DA, Jones D, Textor S, Goff DC, Murphy TP, Toto RD, White A, Cushman WC, White W, Sica D, Ferdinand K, Giles TD, Falkner B, Carey RM . Resistant hypertension: diagnosis, evaluation, and treatment a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research . Circulation 2008. ; 117 : e510 – 526 . - PubMed
    1. Dogru T, Sonmez A, Tasci I, Yilmaz MI, Erdem G, Erturk H, Bignol N, Kilic S, Ozgurtas T . Plasma visfatin levels in young male patients with uncomplicated and newly diagnosed hypertension . J Hum Hypertens 2007. ; 21 : 173 – 175 . - PubMed
    1. Rosenstock J, Raskin P . Hypertension in diabetes mellitus . Cardiol Clin 1988. ; 6 : 547 – 560 . - PubMed

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