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Review
. 2016 Jan 27:9:545-55.
doi: 10.2147/OTT.S95633. eCollection 2016.

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

Zhen-Ge Lei  1 , Xiao-Hua Ren  2 , Sha-Sha Wang  3 , Xin-Hua Liang  4 , Ya-Ling Tang  5
Affiliations
Review

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

Zhen-Ge Lei et al. Onco Targets Ther. .

Abstract

Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.

Keywords: HNSCC; head and neck squamous cell carcinoma; immunocompetent models; immunocompromised models; mouse models; transgenic models.

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Figures

Figure 1
Figure 1
Mouse models of oral cancer. Abbreviations: NOD, nonobese diabetic; SCID, severe combined immunodeficiency; NSG, NOD/SCID gamma.
See this image and copyright information in PMC

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