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. 2015 Nov 21;71(Pt 12):1521-4.
doi: 10.1107/S205698901502191X. eCollection 2015 Dec 1.

Crystal structure of N-[(1S,2S)-2-amino-cyclo-hex-yl]-2,4,6-tri-methyl-benzene-sulfonamide

Felix N Ngassa  1 , Shannon M Biros  1 , Richard J Staples  2
Affiliations

Crystal structure of N-[(1S,2S)-2-amino-cyclo-hex-yl]-2,4,6-tri-methyl-benzene-sulfonamide

Felix N Ngassa et al. Acta Crystallogr E Crystallogr Commun. .

Abstract

The title compound, C15H24N2O2S, was synthesized via a substitution reaction between the enanti-opure (1S,2S)-(+)-1,2-di-amino-cyclo-hexane and 2,4,6-tri-methyl-benzene-1-sulfonyl chloride. The cyclo-hexyl and phenyl substituents are oriented gauche around the sulfonamide S-N bond. In the crystal, mol-ecules are linked via N-H⋯N hydrogen bonds, forming chains propagating along [100].

Keywords: chiral compound; crystal structure; hydrogen bond; sulfonamide.

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Figures

Figure 1
Figure 1
The asymmetric part of the unit cell along with the atom-numbering scheme and displacement ellipsoids drawn at the 50% probability level. An intra­molecular N—H⋯N inter­action is shown with a blue dashed line. Only N—H hydrogens are shown for clarity.
Figure 2
Figure 2
Intra- and inter­molecular hydrogen-bonding inter­actions present in the crystal. Hydrogen bonds are drawn as blue dashed lines. Only N—H hydrogens are shown for clarity. [Symmetry code: (i) x − formula image, −y + formula image, −z + 1.]
See this image and copyright information in PMC

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