Bromodomain Blockade for Intimal Hyperplasia--A Good BET?

Affiliations

Comment

Allison C Ostriker et al. EBioMedicine. 2015.

. 2015 Nov 10;2(11):1574-5.

doi: 10.1016/j.ebiom.2015.11.007. eCollection 2015 Nov.

¹ Department of Cardiovascular Medicine, Cardiovascular Research Center, Vascular Biology and Therapeutics, Yale University School of Medicine, United States.

No abstract available

Comment on

BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries.
Wang B, Zhang M, Takayama T, Shi X, Roenneburg DA, Kent KC, Guo LW. Wang B, et al. EBioMedicine. 2015 Sep 28;2(11):1650-61. doi: 10.1016/j.ebiom.2015.09.045. eCollection 2015 Nov. EBioMedicine. 2015. PMID: 26870791 Free PMC article.

Angioplasty induces epigenomic remodeling in injured arteries.
Zhang M, Urabe G, Ozer HG, Xie X, Webb A, Shirasu T, Li J, Han R, Kent KC, Wang B, Guo LW. Zhang M, et al. Life Sci Alliance. 2022 Feb 15;5(5):e202101114. doi: 10.26508/lsa.202101114. Print 2022 May. Life Sci Alliance. 2022. PMID: 35169042 Free PMC article.
BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs.
Borck PC, Guo LW, Plutzky J. Borck PC, et al. Circ Res. 2020 Apr 24;126(9):1190-1208. doi: 10.1161/CIRCRESAHA.120.315929. Epub 2020 Apr 23. Circ Res. 2020. PMID: 32324495 Free PMC article. Review.
Nano-based perivascular intervention sustains a nine-month long-term suppression of intimal hyperplasia in vein grafts.
Shirasu T, Urabe G, Yodsanit N, Huang Y, Xie R, Stratton MS, Joseph M, Zhang Z, Wang Y, Li J, Tang R, Marcho LM, Yin L, Kent EW, Zhang K, Park KH, Wang B, Kent KC, Gong S, Guo LW. Shirasu T, et al. Bioact Mater. 2024 Oct 13;44:82-96. doi: 10.1016/j.bioactmat.2024.10.005. eCollection 2025 Feb. Bioact Mater. 2024. PMID: 40438256 Free PMC article.

1. Katz G., Harchandani B., Shah B. Drug-eluting stents: the past, present, and future. Curr. Atheroscler. Rep. 2015;17(3):485. - PubMed
1. Liu R., Leslie K.L., Martin K.A. Epigenetic regulation of smooth muscle cell plasticity. Biochim. Biophys. Acta. 2015;1849(4):448–453. - PMC - PubMed
1. Meloche J., Potus F., Vaillancourt M., Bourgeois A., Johnson I., Deschamps L., Chabot S., Ruffenach G., Henry S., Breuils-Bonnet S., Tremblay È., Nadeau V., Lambert C., Paradis R., Provencher S., Bonnet S. Bromodomain-containing protein 4: the epigenetic origin of pulmonary arterial hypertension. Circ. Res. 2015;117(6):525–535. (2015) - PubMed
1. Nicholls S.J., Puri R., Wolski K., Ballantyne C.M., Barter P.J., Brewer H.B., Kastelein J.J., Hu B., Uno K., Kataoka Y., Herrman J.R., Merkely B., Borgman M., Nissen S.E. Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: results of the phase 2b, randomized, double-blind, multicenter, ASSURE trial. Am. J. Cardiovasc. Drugs. 2015 (2015 Sep 18. [Epub ahead of print]) - PubMed
1. Perry M.M., Durham A.L., Austin P.J., Adcock I.M., Chung K.F. BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. J. Biol. Chem. 2015;290(14):9111–9121. - PMC - PubMed