Comment

. 2016 Jan 11:3:4-5.

doi: 10.1016/j.ebiom.2016.01.009. eCollection 2016 Jan.

Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

Michael Danilenko¹, George P Studzinski²

Affiliations

¹ Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel. Electronic address: misha@bgu.ac.il.
² Department of Pathology and Laboratory Medicine, Rutgers-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103, USA.

PMID: 26870832
PMCID: PMC4739434
DOI: 10.1016/j.ebiom.2016.01.009

Comment

Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

Michael Danilenko et al. EBioMedicine. 2016.

. 2016 Jan 11:3:4-5.

doi: 10.1016/j.ebiom.2016.01.009. eCollection 2016 Jan.

Authors

Michael Danilenko¹, George P Studzinski²

Affiliations

¹ Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, P.O. Box 653, Beer Sheva 84105, Israel. Electronic address: misha@bgu.ac.il.
² Department of Pathology and Laboratory Medicine, Rutgers-New Jersey Medical School, 185 South Orange Ave., Newark, NJ 07103, USA.

PMID: 26870832
PMCID: PMC4739434
DOI: 10.1016/j.ebiom.2016.01.009

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Human Leukemic Cells performing Oxidative Phosphorylation (OXPHOS) Generate an Antioxidant Response Independently of Reactive Oxygen species (ROS) Production.
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References

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1. Gocek E., Wang X., Liu X., Liu C.G., Studzinski G.P. MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis. Cancer Res. 2011;71:6230–6239. - PMC - PubMed
1. Harder B., Jiang T., Wu T., Tao S., de la Vega M.R., Tian W., Chapman E., Zhang D.D. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem. Soc. Trans. 2015;43:680–686. - PMC - PubMed
1. Kabaria S., Choi D.C., Chaudhuri A.D., Jain M.R., Li H., Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic. Biol. Med. 2015;89:548–556. - PMC - PubMed
1. Kalsotra A., Singh R.K., Gurha P., Ward A.J., Creighton C.J., Cooper T.A. The Mef2 transcription network is disrupted in myotonic dystrophy heart tissue, dramatically altering miRNA and mRNA expression. Cell Rep. 2014;6:336–345. - PMC - PubMed

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Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

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Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

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