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Comment
. 2016 Feb 11;164(4):595-7.
doi: 10.1016/j.cell.2016.01.050.

Pluripotency without Proliferation

Xiaodong Shu  1 , Duanqing Pei  2
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Free article
Comment

Pluripotency without Proliferation

Xiaodong Shu et al. Cell. .
Free article

Abstract

Mouse embryonic stem cells (mESCs) are capable of unlimited proliferation without losing pluripotency. Scognamiglio et al. now reveal that Myc depletion shifts mESCs into a dormant state reminiscent of embryonic diapause in which pluripotency remains fully preserved, thus decoupling pluripotency from proliferative programs.

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  • Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.
    Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A. Scognamiglio R, et al. Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033. Cell. 2016. PMID: 26871632 Free PMC article.

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