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Comment
. 2016 Feb 11;164(4):601-2.
doi: 10.1016/j.cell.2016.01.031.

A New Way to Diversify Antibodies by DNA Transposition

Davide F Robbiani  1 , Michel C Nussenzweig  2
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Comment

A New Way to Diversify Antibodies by DNA Transposition

Davide F Robbiani et al. Cell. .
Free article

Abstract

While searching for new therapeutics against malaria, Lanzavecchia and colleagues discovered that antibodies can be diversified by DNA sequences encoded outside of antibody genes.

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  • A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
    Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. Tan J, et al. Nature. 2016 Jan 7;529(7584):105-109. doi: 10.1038/nature16450. Epub 2015 Dec 23. Nature. 2016. PMID: 26700814 Free PMC article.

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