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. 2016 Feb 15;193(4):464-6.
doi: 10.1164/rccm.201509-1872LE.

MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis

Yasushi Nakano  1 , Ivana V Yang  1 , Avram D Walts  1 , Alan M Watson  1 , Britney A Helling  1 , Ashley A Fletcher  1 , Abigail R Lara  1 , Marvin I Schwarz  1 , Christopher M Evans  1 , David A Schwartz  1
Affiliations

MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis

Yasushi Nakano et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Effects of site-directed mutagenesis of the MUC5B promoter variant. MUC5B promoter activity of the TT group was significantly higher than that of the GG group in the A549 cell line. Data are represented as mean ± SEM (n = 5, 6) and significance assessed with an unpaired one-tailed Mann-Whitney U test (P = 0.002).
Figure 2.
Figure 2.
Correlation between MUC5B promoter activity and percentage of MUC5B-positive area of the small airway epithelium in idiopathic pulmonary fibrosis lung. Solid circles represent GG samples, and open circles represent TT samples. A Spearman correlation coefficient test (one-tailed) was used to analyze these data. r = 0.86; P = 0.0003.
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References

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    1. Nakano YEC, Yang IV, Schwarz MI, Schwartz DA.Muc5b promoter variant rs35705950 effects muc5b expression and this effect is localized to the distal airways in IPF [abstract] Am J Respir Crit Care Med 2015191A3858 - PMC - PubMed
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