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Multicenter Study
. 2016 Feb 12;11(2):e0147928.
doi: 10.1371/journal.pone.0147928. eCollection 2016.

A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt

Olivier Manigart  1   2 , Caroline Trotter  3 , Helen Findlow  4 , Abraham Assefa  5 , Wude Mihret  5 , Tesfaye Moti Demisse  5 , Biruk Yeshitela  5 , Isaac Osei  6 , Abraham Hodgson  6 , Stephen Laryea Quaye  6 , Samba Sow  7 , Mamadou Coulibaly  7 , Kanny Diallo  7 , Awa Traore  7 , Jean-Marc Collard  8 , Rahamatou Moustapha Boukary  8 , Oumarou Djermakoye  8 , Ali Elhaji Mahamane  8 , Jean-François Jusot  8 , Cheikh Sokhna  9 , Serge Alavo  9 , Souleymane Doucoure  9 , El Hadj Ba  9 , Mariétou Dieng  9 , Aldiouma Diallo  9 , Doumagoum Moto Daugla  10 , Babatunji Omotara  11 , Daniel Chandramohan  1 , Musa Hassan-King  1 , Maria Nascimento  1 , Arouna Woukeu  1 , Ray Borrow  4 , James M Stuart  1 , Brian Greenwood  1
Affiliations
Multicenter Study

A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt

Olivier Manigart et al. PLoS One. .

Erratum in

  • Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt.
    Manigart O, Trotter C, Findlow H, Aseffa A, Mihret W, Moti Demisse T, Yeshitela B, Osei I, Hodgson A, Quaye SL, Sow S, Coulibaly M, Diallo K, Traore A, Collard JM, Moustapha Boukary R, Djermakoye O, Mahamane AE, Jusot JF, Sokhna C, Alavo S, Doucoure S, Ba EH, Dieng M, Diallo A, Daugla DM, Omotara B, Chandramohan D, Hassan-King M, Nascimento M, Woukeu A, Borrow R, Stuart JM, Greenwood B. Manigart O, et al. PLoS One. 2016 Jul 5;11(7):e0158938. doi: 10.1371/journal.pone.0158938. eCollection 2016. PLoS One. 2016. PMID: 27379429 Free PMC article.

Abstract

The pattern of epidemic meningococcal disease in the African meningitis belt may be influenced by the background level of population immunity but this has been measured infrequently. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was established at five centres within the meningitis belt. Antibody concentrations were then measured in 3930 individuals stratified by age and residence from six countries. Seroprevalence by age was used in a catalytic model to determine the force of infection. Meningococcal serogroup A IgG antibody concentrations were high in each country but showed heterogeneity across the meningitis belt. The geometric mean concentration (GMC) was highest in Ghana (9.09 μg/mL [95% CI 8.29, 9.97]) and lowest in Ethiopia (1.43 μg/mL [95% CI 1.31, 1.57]) on the margins of the belt. The force of infection was lowest in Ethiopia (λ = 0.028). Variables associated with a concentration above the putative protective level of 2 μg/mL were age, urban residence and a history of recent vaccination with a meningococcal vaccine. Prior to vaccination with the serogroup A meningococcal conjugate vaccine, meningococcal serogroup A IgG antibody concentrations were high across the African meningitis belt and yet the region remained susceptible to epidemics.

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Conflict of interest statement

Competing Interests: HF and RB report performing contract resarch on behalf of Public Health England for Novartis Vaccines and Diagnostics, Baxter Biosciences, GlaxoSmithKline, Pfizer, Sanofi Pasteur and Serum Institute of India. CT reports receiving a consulting payment from GlaxoSmithKline. All other authors report no conflict of interest. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Reverse cumulative distribution curves of meningococcal serogroup A IgG antibodies by country.
Fig 2
Fig 2. Statistical analysis of seropositivity data for all individuals.
Age-adjusted seroprevalence (blue solid lines) using appropriate reversible catalytic models. The observed seroprevalences (red-filled triangles) were pooled according to the 10%-centiles of the underlying age distribution.
Fig 3
Fig 3. Statistical analysis of seropositivity data excluding vaccinated individuals.
Age-adjusted seroprevalence (blue solid lines) using appropriate reversible catalytic models. The observed seroprevalences (red-filled triangles) were pooled according to the 10%-centiles of the underlying age distribution.
See this image and copyright information in PMC

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  • Correction: A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt.
    Manigart O, Trotter C, Findlow H, Aseffa A, Mihret W, Moti Demisse T, Yeshitela B, Osei I, Hodgson A, Quaye SL, Sow S, Coulibaly M, Diallo K, Traore A, Collard JM, Moustapha Boukary R, Djermakoye O, Mahamane AE, Jusot JF, Sokhna C, Alavo S, Doucoure S, Ba EH, Dieng M, Diallo A, Daugla DM, Omotara B, Chandramohan D, Hassan-King M, Nascimento M, Woukeu A, Borrow R, Stuart JM, Greenwood B. Manigart O, et al. PLoS One. 2016 Jul 5;11(7):e0158938. doi: 10.1371/journal.pone.0158938. eCollection 2016. PLoS One. 2016. PMID: 27379429 Free PMC article.
  • Meningococcal serogroup B vaccines: Estimating breadth of coverage.
    Donald RG, Hawkins JC, Hao L, Liberator P, Jones TR, Harris SL, Perez JL, Eiden JJ, Jansen KU, Anderson AS. Donald RG, et al. Hum Vaccin Immunother. 2017 Feb;13(2):255-265. doi: 10.1080/21645515.2017.1264750. Epub 2016 Dec 14. Hum Vaccin Immunother. 2017. PMID: 27960595 Free PMC article. Review.

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